Primary invasive laryngeal mycosis in an immunocompetent patient: a case report and clinico-epidemiological update

Laryngeal aspergillosis is uncommon and is usually secondary to pulmonary involvement in immunocompromised patients. Primary laryngeal aspergillosis in immunocompetent individuals is extremely rare, with a few cases documented over the last five decades. We report a case of primary localised larynge...

Full description

Saved in:
Bibliographic Details
Published in:BMC infectious diseases 2018-07, Vol.18 (1), p.323-323, Article 323
Main Authors: Subramanya, Supram Hosuru, Jillwin, Joseph, Rudramurthy, Shivaprakash Mandya, Rijal, Krishna Chandra, Nayak, Niranjan, Chakrabarti, Arunaloke, Ghosh, Arnab
Format: Article
Language:English
Subjects:
Alcohol
Aspergillosis
Aspergillus
Aspergillus fumigatus
Biopsy
Care and treatment
Case Report
Case reports
Causes of
Deoxyribonucleic acid
DNA
DNA sequencing
Dosage and administration
Edema
Epidemiology
Etiology
FFPE-PCR
Fungal infections
Fungi
Histopathology
Hyphae
Immunocompetence
Immunocompromised hosts
Infectious diseases
Itraconazole
Laryngitis
Larynx
Leukemia
Mycosis
Paraffin
Paraffins
Primary laryngeal aspergillosis
Thermal cycling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Laryngeal aspergillosis is uncommon and is usually secondary to pulmonary involvement in immunocompromised patients. Primary laryngeal aspergillosis in immunocompetent individuals is extremely rare, with a few cases documented over the last five decades. We report a case of primary localised laryngeal aspergillosis in a 21-year-old apparently immunocompetent student. Septate hyphae were observed on histopathology of the laryngeal lesion, which was further confirmed as Aspergillus fumigatus after extraction of fungal DNA from formalin fixed paraffin embedded tissue (FFPET) and sequencing. The patient responded well to oral itraconazole therapy over a month. Since last few decades, cases of primary laryngeal aspergillosis in immunocompetent individuals are on the rise, globally. This is the first case of invasive laryngeal aspergillosis reported in Nepal. The extraction of DNA from tissue and sequencing helps to identify the etiological agent, when culture fails to isolate the fungus.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-018-3219-1