Circular RNAs in cancer: new insights into functions and implications in ovarian cancer

Circular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse RNA molecules with a range of activities such as translation and splicing regulation, which are able to interacting with RNA-bind...

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Bibliographic Details
Published in:Journal of ovarian research 2019-09, Vol.12 (1), p.84-84, Article 84
Main Authors: Shabaninejad, Zahra, Vafadar, Asma, Movahedpour, Ahmad, Ghasemi, Younes, Namdar, Afshin, Fathizadeh, Hadis, Pourhanifeh, Mohammad Hossein, Savardashtaki, Amir, Mirzaei, Hamed
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Apoptosis
Binding proteins
Biological markers
Biosynthesis
Cancer metastasis
Cell cycle
Cell proliferation
Circular RNA
Dentistry
Development and progression
Enzymes
Female
Gene expression
Genetic aspects
Health aspects
Humans
Medical prognosis
Metastases
MicroRNA
MicroRNAs
miRNA
Molecular modelling
Novels
Ovarian cancer
Ovarian Neoplasms - genetics
Pharmaceutical sciences
Physiological aspects
Protein binding
Proteins
Research centers
Review
RNA
RNA polymerase
RNA, Circular
RNA-binding protein
Splicing
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Summary:Circular RNAs (circRNAs) are a class of long non-coding RNAs (lncRNAs) which have a circular and closed loop structure. They are ubiquitous, stable, conserved and diverse RNA molecules with a range of activities such as translation and splicing regulation, which are able to interacting with RNA-binding proteins and specially miRNA sponge. The expression patterns of the circRNAs exhibited tissue specificity and also, step and stage specificity. Accumulating evidences approved the critical role of circular RNAs in many cancers such as ovarian cancer. Given that these molecules exert their effects through multiple cellular and molecular mechanisms (i.e., angiogenesis, apoptosis, growth, and metastasis) which are involved in cancer pathogenesis, circular RNAs, in particular, act by controlling cell proliferation in ovarian cancer, so that, it has been shown that the deregulation of these molecules is associated with initiation and progression of ovarian cancer. Therefore, they are attractive molecules which have introduced them as cancer biomarkers. Moreover, they could be used as new therapeutic candidates for developing novel treatment strategies. Here, for first time, we have provided a comprehensive review on the recent knowledge of circular RNAs and their pathological roles in the ovarian cancer.
ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-019-0558-5