Edwardsiella tarda OmpA Encapsulated in Chitosan Nanoparticles Shows Superior Protection over Inactivated Whole Cell Vaccine in Orally Vaccinated Fringed-Lipped Peninsula Carp (Labeo fimbriatus)

The use of oral vaccination in finfish has lagged behind injectable vaccines for a long time as oral vaccines fall short of injection vaccines in conferring protective immunity. Biodegradable polymeric nanoparticles (NPs) have shown potential to serve as antigen delivery systems for oral vaccines. I...

Full description

Saved in:
Bibliographic Details
Published in:Vaccines (Basel) 2016-11, Vol.4 (4), p.40-40
Main Authors: Dubey, Saurabh, Avadhani, Kiran, Mutalik, Srinivas, Sivadasan, Sangeetha Madambithara, Maiti, Biswajit, Girisha, Shivani Kallappa, Venugopal, Moleyur Nagarajappa, Mutoloki, Stephen, Evensen, Øystein, Karunasagar, Indrani, Munang’andu, Hetron Mweemba
Format: Article
Language:English
Subjects:
Bacterial proteins
Biodegradation
carp
chitosan
CRE bacteria
Drug delivery systems
Edwardsiella tarda
Fish
Labeo fimbriatus
nanoparticle
Nanoparticles
oral
outer membrane protein
vaccination
Vaccines
Zeta potential
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of oral vaccination in finfish has lagged behind injectable vaccines for a long time as oral vaccines fall short of injection vaccines in conferring protective immunity. Biodegradable polymeric nanoparticles (NPs) have shown potential to serve as antigen delivery systems for oral vaccines. In this study the recombinant outer membrane protein A (rOmpA) of was encapsulated in chitosan NPs (NP-rOmpA) and used for oral vaccination of . The rOmpA purity was 85%, nanodiameter
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines4040040