Multisequence magnetic resonance neurography of brachial and lumbosacral plexus in chronic inflammatory demyelinating polyneuropathy: correlations with electrophysiological parameters and clinical features

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare and challenging demyelinating disorder. It is necessary to increase our understanding of potential connections between imaging, electromyography, and clinical characteristics. Objective: The aim of this study was to evalu...

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Published in:Therapeutic advances in neurological disorders 2023-01, Vol.16, p.17562864221150540-17562864221150540
Main Authors: Su, Xiaoyun, Kong, Xiangquan, Kong, Xiangchuang, Zhu, Qing, Lu, Zuneng, Zheng, Chuansheng
Format: Article
Language:English
Subjects:
Action potential
Anisotropy
Cerebrospinal fluid
Demyelination
Diffusion coefficient
Electromyography
Inflammation
Latency
Magnetic resonance imaging
Muscle strength
Myelin
Nerve conduction
Neurotrophin 2
Original Research
Physical characteristics
Polyneuropathy
Rods
Sensory neurons
Velocity
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Summary:Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare and challenging demyelinating disorder. It is necessary to increase our understanding of potential connections between imaging, electromyography, and clinical characteristics. Objective: The aim of this study was to evaluate the relationships between multisequence magnetic resonance neurography (MRN) findings, electrophysiological parameters, and clinical characteristics in CIDP patients. Design: A cross-sectional study. Methods: Overall, 51 CIDP patients underwent MRN of the brachial and lumbosacral plexus, and nerve conduction studies. The inflammatory Rasch-built overall disability scale (I-RODS) questionnaire, CIDP disease activity status (CADS) scale, and muscle strength scores were evaluated by two neurologists. Electrophysiological parameters, clinical information, and multiparameter-MRN were analyzed for correlations. Multiparameter-MRN includes diameter, nerve-to-muscle T2 signal intensity ratio (nT2), contrast-enhanced ratio (CR), fractional anisotropy (FA), and apparent diffusion coefficient (ADC) of bilateral plexus nerve roots. Results: Electrophysiological parameters that were not elicited were significantly higher in the lower extremities than in the upper extremities, and those were higher in sensory nerve conduction than in motor. There were moderate correlations between motor nerve conduction velocity and distal motor latency in nerve diameter, nT2, FA, and ADC, respectively (|r|, 0.45–0.64, p 
ISSN:1756-2864
1756-2856
1756-2864
DOI:10.1177/17562864221150540