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Evolution of the Proto Sex-Chromosome in Solea senegalensis
is a flatfish belonging to the Soleidae family within the Pleuronectiformes order. It has a karyotype of 2 = 42 (FN = 60; 6M + 4 SM + 8 St + 24 T) and a XX/XY system. The first pair of metacentric chromosomes has been proposed as a proto sex-chromosome originated by a Robertsonian fusion between acr...
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| Published in: | International journal of molecular sciences 2019-10, Vol.20 (20), p.5111 |
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| container_title | International journal of molecular sciences |
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| creator | Rodríguez, María Esther Molina, Belén Merlo, Manuel Alejandro Arias-Pérez, Alberto Portela-Bens, Silvia García-Angulo, Aglaya Cross, Ismael Liehr, Thomas Rebordinos, Laureana |
| description | is a flatfish belonging to the Soleidae family within the Pleuronectiformes order. It has a karyotype of 2
= 42 (FN = 60; 6M + 4 SM + 8 St + 24 T) and a XX/XY system. The first pair of metacentric chromosomes has been proposed as a proto sex-chromosome originated by a Robertsonian fusion between acrocentric chromosomes. In order to elucidate a possible evolutionary origin of this chromosome 1, studies of genomic synteny were carried out with eight fish species. A total of 88 genes annotated within of 14 BACs located in the chromosome 1 of
were used to elaborate syntenic maps. Six BACs (BAC5K5, BAC52C17, BAC53B20, BAC84K7, BAC56H24, and BAC48P7) were distributed in, at least, 5 chromosomes in the species studied, and a group of four genes from BAC53B20 (
,
,
and
) and genes from BAC48K7 (
,
,
,
,
and
) formed a conserved cluster in all species. The analysis of repetitive sequences showed that the number of retroelements and simple repeat per BAC showed its highest value in the subcentromeric region where 53B20, 16E16 and 48K7 BACs were localized. This region contains all the
genes, which are associated with sex determination in some species. In addition, the presence of a satellite "chromosome Y" (motif length: 860 bp) was detected in this region. These findings allowed to trace an evolutionary trend for the large metacentric chromosome of
throughout different rearrangements, which could be at an initial phase of differentiation as sex chromosome. |
| doi_str_mv | 10.3390/ijms20205111 |
| format | article |
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= 42 (FN = 60; 6M + 4 SM + 8 St + 24 T) and a XX/XY system. The first pair of metacentric chromosomes has been proposed as a proto sex-chromosome originated by a Robertsonian fusion between acrocentric chromosomes. In order to elucidate a possible evolutionary origin of this chromosome 1, studies of genomic synteny were carried out with eight fish species. A total of 88 genes annotated within of 14 BACs located in the chromosome 1 of
were used to elaborate syntenic maps. Six BACs (BAC5K5, BAC52C17, BAC53B20, BAC84K7, BAC56H24, and BAC48P7) were distributed in, at least, 5 chromosomes in the species studied, and a group of four genes from BAC53B20 (
,
,
and
) and genes from BAC48K7 (
,
,
,
,
and
) formed a conserved cluster in all species. The analysis of repetitive sequences showed that the number of retroelements and simple repeat per BAC showed its highest value in the subcentromeric region where 53B20, 16E16 and 48K7 BACs were localized. This region contains all the
genes, which are associated with sex determination in some species. In addition, the presence of a satellite "chromosome Y" (motif length: 860 bp) was detected in this region. These findings allowed to trace an evolutionary trend for the large metacentric chromosome of
throughout different rearrangements, which could be at an initial phase of differentiation as sex chromosome.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms20205111</identifier><identifier>PMID: 31618912</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal behavior ; Animals ; Chromosome 1 ; chromosome evolution ; Chromosome Mapping ; Chromosomes ; Cloning ; Evolution ; Evolution, Molecular ; Female ; Fish ; Flatfishes - genetics ; Gene expression ; Gene mapping ; Genes ; genomic synteny ; Genomics - methods ; Karyotype ; Karyotypes ; Karyotyping ; Kinases ; Male ; repetitive sequences ; Repetitive Sequences, Nucleic Acid ; Sequences ; Sex Chromosomes ; Sex determination ; Solea senegalensis ; Synteny ; Y chromosomes</subject><ispartof>International journal of molecular sciences, 2019-10, Vol.20 (20), p.5111</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-14b0dba05e967cf525390b25be59d2c236be907a4fd40635711914b111a7a5243</citedby><cites>FETCH-LOGICAL-c478t-14b0dba05e967cf525390b25be59d2c236be907a4fd40635711914b111a7a5243</cites><orcidid>0000-0002-4475-2170 ; 0000-0001-8967-4519 ; 0000-0003-1672-3054 ; 0000-0001-5269-2182</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2548610577/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2548610577?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31618912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez, María Esther</creatorcontrib><creatorcontrib>Molina, Belén</creatorcontrib><creatorcontrib>Merlo, Manuel Alejandro</creatorcontrib><creatorcontrib>Arias-Pérez, Alberto</creatorcontrib><creatorcontrib>Portela-Bens, Silvia</creatorcontrib><creatorcontrib>García-Angulo, Aglaya</creatorcontrib><creatorcontrib>Cross, Ismael</creatorcontrib><creatorcontrib>Liehr, Thomas</creatorcontrib><creatorcontrib>Rebordinos, Laureana</creatorcontrib><title>Evolution of the Proto Sex-Chromosome in Solea senegalensis</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>is a flatfish belonging to the Soleidae family within the Pleuronectiformes order. It has a karyotype of 2
= 42 (FN = 60; 6M + 4 SM + 8 St + 24 T) and a XX/XY system. The first pair of metacentric chromosomes has been proposed as a proto sex-chromosome originated by a Robertsonian fusion between acrocentric chromosomes. In order to elucidate a possible evolutionary origin of this chromosome 1, studies of genomic synteny were carried out with eight fish species. A total of 88 genes annotated within of 14 BACs located in the chromosome 1 of
were used to elaborate syntenic maps. Six BACs (BAC5K5, BAC52C17, BAC53B20, BAC84K7, BAC56H24, and BAC48P7) were distributed in, at least, 5 chromosomes in the species studied, and a group of four genes from BAC53B20 (
,
,
and
) and genes from BAC48K7 (
,
,
,
,
and
) formed a conserved cluster in all species. The analysis of repetitive sequences showed that the number of retroelements and simple repeat per BAC showed its highest value in the subcentromeric region where 53B20, 16E16 and 48K7 BACs were localized. This region contains all the
genes, which are associated with sex determination in some species. In addition, the presence of a satellite "chromosome Y" (motif length: 860 bp) was detected in this region. These findings allowed to trace an evolutionary trend for the large metacentric chromosome of
throughout different rearrangements, which could be at an initial phase of differentiation as sex chromosome.</description><subject>Animal behavior</subject><subject>Animals</subject><subject>Chromosome 1</subject><subject>chromosome evolution</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Cloning</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Female</subject><subject>Fish</subject><subject>Flatfishes - genetics</subject><subject>Gene expression</subject><subject>Gene mapping</subject><subject>Genes</subject><subject>genomic synteny</subject><subject>Genomics - methods</subject><subject>Karyotype</subject><subject>Karyotypes</subject><subject>Karyotyping</subject><subject>Kinases</subject><subject>Male</subject><subject>repetitive sequences</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Sequences</subject><subject>Sex Chromosomes</subject><subject>Sex determination</subject><subject>Solea senegalensis</subject><subject>Synteny</subject><subject>Y chromosomes</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkdFLHDEQxoNU1F775rMs9KUPrk0myWZDQSiHVUFowfY5ZLOzdzl2NzbZlfa_N3oqZ58yJN_8Zr58hBwzesa5pl_8ZkhAgUrG2B45YgKgpLRS73bqQ_I-pQ2lwEHqA3LIWcVqzeCIfL24D_08-TAWoSumNRY_Y5hCcYt_y-U6hiGkMGDhx-I29GiLhCOubI9j8ukD2e9sn_Dj87kgv79f_FpelTc_Lq-X325KJ1Q9lUw0tG0slagr5ToJMq_dgGxQ6hYc8KpBTZUVXStoxaViTOeebMcqK0HwBbnecttgN-Yu-sHGfyZYb54uQlwZGyfvejRKtAid5NJ1IJyum9bSSghqLXOZ2mbW-ZZ1NzcDtg7HKdr-DfTty-jXZhXuTVWDFkplwOdnQAx_ZkyTGXxy2Pd2xDAnAzwP1Jxllwvy6T_pJsxxzF9lQIq6YlQ-AU-3KhdDShG712UYNY8Jm92Es_xk18Cr-CVS_gBN9Z_3</recordid><startdate>20191015</startdate><enddate>20191015</enddate><creator>Rodríguez, María Esther</creator><creator>Molina, Belén</creator><creator>Merlo, Manuel Alejandro</creator><creator>Arias-Pérez, Alberto</creator><creator>Portela-Bens, Silvia</creator><creator>García-Angulo, Aglaya</creator><creator>Cross, Ismael</creator><creator>Liehr, Thomas</creator><creator>Rebordinos, Laureana</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4475-2170</orcidid><orcidid>https://orcid.org/0000-0001-8967-4519</orcidid><orcidid>https://orcid.org/0000-0003-1672-3054</orcidid><orcidid>https://orcid.org/0000-0001-5269-2182</orcidid></search><sort><creationdate>20191015</creationdate><title>Evolution of the Proto Sex-Chromosome in Solea senegalensis</title><author>Rodríguez, María Esther ; Molina, Belén ; Merlo, Manuel Alejandro ; Arias-Pérez, Alberto ; Portela-Bens, Silvia ; García-Angulo, Aglaya ; Cross, Ismael ; Liehr, Thomas ; Rebordinos, Laureana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-14b0dba05e967cf525390b25be59d2c236be907a4fd40635711914b111a7a5243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal behavior</topic><topic>Animals</topic><topic>Chromosome 1</topic><topic>chromosome evolution</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Cloning</topic><topic>Evolution</topic><topic>Evolution, Molecular</topic><topic>Female</topic><topic>Fish</topic><topic>Flatfishes - genetics</topic><topic>Gene expression</topic><topic>Gene mapping</topic><topic>Genes</topic><topic>genomic synteny</topic><topic>Genomics - methods</topic><topic>Karyotype</topic><topic>Karyotypes</topic><topic>Karyotyping</topic><topic>Kinases</topic><topic>Male</topic><topic>repetitive sequences</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Sequences</topic><topic>Sex Chromosomes</topic><topic>Sex determination</topic><topic>Solea senegalensis</topic><topic>Synteny</topic><topic>Y chromosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez, María Esther</creatorcontrib><creatorcontrib>Molina, Belén</creatorcontrib><creatorcontrib>Merlo, Manuel Alejandro</creatorcontrib><creatorcontrib>Arias-Pérez, Alberto</creatorcontrib><creatorcontrib>Portela-Bens, Silvia</creatorcontrib><creatorcontrib>García-Angulo, Aglaya</creatorcontrib><creatorcontrib>Cross, Ismael</creatorcontrib><creatorcontrib>Liehr, Thomas</creatorcontrib><creatorcontrib>Rebordinos, Laureana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez, María Esther</au><au>Molina, Belén</au><au>Merlo, Manuel Alejandro</au><au>Arias-Pérez, Alberto</au><au>Portela-Bens, Silvia</au><au>García-Angulo, Aglaya</au><au>Cross, Ismael</au><au>Liehr, Thomas</au><au>Rebordinos, Laureana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of the Proto Sex-Chromosome in Solea senegalensis</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2019-10-15</date><risdate>2019</risdate><volume>20</volume><issue>20</issue><spage>5111</spage><pages>5111-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>is a flatfish belonging to the Soleidae family within the Pleuronectiformes order. It has a karyotype of 2
= 42 (FN = 60; 6M + 4 SM + 8 St + 24 T) and a XX/XY system. The first pair of metacentric chromosomes has been proposed as a proto sex-chromosome originated by a Robertsonian fusion between acrocentric chromosomes. In order to elucidate a possible evolutionary origin of this chromosome 1, studies of genomic synteny were carried out with eight fish species. A total of 88 genes annotated within of 14 BACs located in the chromosome 1 of
were used to elaborate syntenic maps. Six BACs (BAC5K5, BAC52C17, BAC53B20, BAC84K7, BAC56H24, and BAC48P7) were distributed in, at least, 5 chromosomes in the species studied, and a group of four genes from BAC53B20 (
,
,
and
) and genes from BAC48K7 (
,
,
,
,
and
) formed a conserved cluster in all species. The analysis of repetitive sequences showed that the number of retroelements and simple repeat per BAC showed its highest value in the subcentromeric region where 53B20, 16E16 and 48K7 BACs were localized. This region contains all the
genes, which are associated with sex determination in some species. In addition, the presence of a satellite "chromosome Y" (motif length: 860 bp) was detected in this region. These findings allowed to trace an evolutionary trend for the large metacentric chromosome of
throughout different rearrangements, which could be at an initial phase of differentiation as sex chromosome.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31618912</pmid><doi>10.3390/ijms20205111</doi><orcidid>https://orcid.org/0000-0002-4475-2170</orcidid><orcidid>https://orcid.org/0000-0001-8967-4519</orcidid><orcidid>https://orcid.org/0000-0003-1672-3054</orcidid><orcidid>https://orcid.org/0000-0001-5269-2182</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2019-10, Vol.20 (20), p.5111 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_74de2f535cf24c98bda06440aa1c191d |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Animal behavior Animals Chromosome 1 chromosome evolution Chromosome Mapping Chromosomes Cloning Evolution Evolution, Molecular Female Fish Flatfishes - genetics Gene expression Gene mapping Genes genomic synteny Genomics - methods Karyotype Karyotypes Karyotyping Kinases Male repetitive sequences Repetitive Sequences, Nucleic Acid Sequences Sex Chromosomes Sex determination Solea senegalensis Synteny Y chromosomes |
| title | Evolution of the Proto Sex-Chromosome in Solea senegalensis |
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