Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate

Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities. The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other envir...

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Bibliographic Details
Published in:Stem cells international 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Bertucci, Taylor B., Dai, Guohao
Format: Article
Language:English
Subjects:
Amino acids
Biological products
Biomaterials
Biomedical materials
Cell culture
Cell fate
Cell self-renewal
Collagen
Cues
Design
Differentiation
Engineering
Environmental engineering
Hydrogels
Hydroxyapatite
Peptides
Photochemistry
Platforms
Pluripotency
Polylactic acid
Proteins
Regenerative medicine
Researchers
Review
Stem cells
Stiffness
Therapeutic applications
Tissue engineering
Transplants & implants
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Summary:Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities. The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other environmental signals are beginning to be explored using biomaterial platforms. Biomaterials offer new opportunities to engineer the stem cell niches and 3D environments for exploring biophysical and immobilized signaling cues to further our control over stem cell fate. Here, we review the biomaterial platforms that have been engineered to control PSC fate. We explore how altering immobilized biochemical cues and biophysical cues such as dimensionality, stiffness, and topography can enhance our control over stem cell fates. Finally, we highlight biomaterial culture systems that assist in the translation of PSC technologies for clinical applications.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2018/9068203