Timing of immunotherapeutic strategies for first-episode Isolated Anti-Myelin Oligodendrocyte Glycoprotein-IgG Associated Optic Neuritis: A single-centre retrospective study

There is no consensus on the timing of immunotherapeutic strategies for the first-episode anti-myelin oligodendrocyte glycoprotein-IgG (MOG-IgG) associated disorders (MOGAD) presenting with isolated optic neuritis (ON). To investigate the optimal timing of intravenous methylprednisolone therapy (IVM...

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Bibliographic Details
Published in:Heliyon 2024-06, Vol.10 (12), p.e33263, Article e33263
Main Authors: Zhao, Juan, Meng, Chao, Jiang, Hanqiu, Lai, Chuntao, Guo, Yanjun, Zhu, Liping, Wang, Jiawei
Format: Article
Language:English
Subjects:
adults
blood serum
confidence interval
First-episode
gender
immunosuppression
immunotherapy
intravenous injection
Methylprednisolone
MOG
Mycophenolate mofetil
odds ratio
oligodendroglia
Optic neuritis
Prognosis
regression analysis
Relapse
retrospective studies
vision
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Summary:There is no consensus on the timing of immunotherapeutic strategies for the first-episode anti-myelin oligodendrocyte glycoprotein-IgG (MOG-IgG) associated disorders (MOGAD) presenting with isolated optic neuritis (ON). To investigate the optimal timing of intravenous methylprednisolone therapy (IVMP) and necessity of immunosuppressive therapy for the first-episode isolated MOG-IgG associated ON (iMOG-ON). Adult patients with the first-episode iMOG-ON were enrolled. Primary outcomes were best-corrected visual acuity (BCVA) at last follow-up (i.e. final BCVA) and relapse, and their predictors were assessed by multivariate analysis. 62 patients were included. Logistic regression analysis revealed BCVA at the time of IVMP (odds ratio: 0.463 (95 % confidence interval (CI) 0.310-0.714) was a factor predictive of regaining a final BCVA of 0.0 logMAR vision, and its Youden optimal criterion was
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e33263