Effectiveness of Vitamin-E-Doped Polyethylene in Joint Replacement: A Literature Review

Since polyethylene is one of the most frequently used biomaterials, such as in bearing components in joint arthroplasty, strong efforts have been made to improve the design and material properties over the last decades. Antioxidants, such as vitamin-E, seem to be a promising alternative to further i...

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Bibliographic Details
Published in:Journal of Functional Biomaterials 2015-09, Vol.6 (3), p.889-900
Main Authors: Gigante, Antonio, Bottegoni, Carlo, Ragone, Vincenza, Banci, Lorenzo
Format: Article
Language:English
Subjects:
polyethylene
Review
total joints replacement
vitamin E stabilized UHMPWE
α-tocopherol
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Summary:Since polyethylene is one of the most frequently used biomaterials, such as in bearing components in joint arthroplasty, strong efforts have been made to improve the design and material properties over the last decades. Antioxidants, such as vitamin-E, seem to be a promising alternative to further increase durability and reduce polyethylene wear and degradation in the long-term. Nevertheless, even if several promising in vitro results are available, there is yet no clinical evidence that vitamin-E polyethylenes show these advantages in vivo. The aim of this paper was to provide a comprehensive overview on the current knowledge regarding the biological and mechanical proprieties of this biomaterial, underlying the in vitro and in vivo evidence for effectiveness of vitamin-E-doped polyethylene in joint arthroplasty.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb6030889