Skin Protection by Carotenoid Pigments

Sunlight, despite its benefits, can pose a threat to the skin, which is a natural protective barrier. Phototoxicity caused by overexposure, especially to ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e.,...

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Published in:International journal of molecular sciences 2024-02, Vol.25 (3), p.1431
Main Authors: Flieger, Jolanta, Raszewska-Famielec, Magdalena, Radzikowska-Büchner, Elżbieta, Flieger, Wojciech
Format: Article
Language:English
Subjects:
Antioxidants
Carotenoids
Chlorophyll
Classification
Cosmic rays
Energy
Erythema
Health aspects
Infrared radiation
Isoflavones
Melanoma
nanoformulations
Oxidative stress
Photosynthesis
photosynthetic pigments
Plant products
Polymerization
Polyphenols
Radiation, Background
Skin
Skin cancer
skin photodamage
skin photoprotection
Sunburn & sun tanning
UV protection
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Summary:Sunlight, despite its benefits, can pose a threat to the skin, which is a natural protective barrier. Phototoxicity caused by overexposure, especially to ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e., polyphenols, flavonoids, and photosynthetic pigments, can protect the skin against the effects of radiation, acting not only as photoprotectors like natural filters but as antioxidant and anti-inflammatory remedies, alleviating the effects of photodamage to the skin. Plant-based formulations are gaining popularity as an attractive alternative to synthetic filters. Over the past 20 years, a large number of studies have been published to assess the photoprotective effects of natural plant products, primarily through their antioxidant, antimutagenic, and anti-immunosuppressive activities. This review selects the most important data on skin photodamage and photoprotective efficacy of selected plant carotenoid representatives from in vivo studies on animal models and humans, as well as in vitro experiments performed on fibroblast and keratinocyte cell lines. Recent research on carotenoids associated with lipid nanoparticles, nanoemulsions, liposomes, and micelles is reviewed. The focus was on collecting those nanomaterials that serve to improve the bioavailability and stability of carotenoids as natural antioxidants with photoprotective activity.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25031431