Antiphospholipid Antibody Syndrome and Infertility

Antiphospholipid antibody syndrome (APS) is a systemic, autoimmune, prothrombotic disease characterized by persistent antiphospholipid antibodies (aPLs), thrombosis, recurrent abortion, complications during pregnancy, and occasionally thrombocytopenia. The objective of the present study was to revie...

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Bibliographic Details
Published in:Revista Brasileira de ginecologia e obstetrícia 2019-10, Vol.41 (10), p.621-627
Main Authors: Rodrigues, Vivian de Oliveira, Soligo, Adriana de Góes E Silva, Pannain, Gabriel Duque
Format: Article
Language:English
Subjects:
Abortion, Habitual
Adult
Antibodies, Antiphospholipid - blood
antiphospholipid antibody
antiphospholipid antibody syndrome
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - physiopathology
Female
Humans
infertility
Infertility, Female - complications
Infertility, Female - physiopathology
Middle Aged
OBSTETRICS & GYNECOLOGY
Pregnancy
recurrent abortion
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Summary:Antiphospholipid antibody syndrome (APS) is a systemic, autoimmune, prothrombotic disease characterized by persistent antiphospholipid antibodies (aPLs), thrombosis, recurrent abortion, complications during pregnancy, and occasionally thrombocytopenia. The objective of the present study was to review the pathophysiology of APS and its association with female infertility. A bibliographic review of articles of the past 20 years was performed at the PubMed, Scielo, and Bireme databases. Antiphospholipid antibody syndrome may be associated with primary infertility, interfering with endometrial decidualization and with decreased ovarian reserve. Antiphospholipid antibodies also have direct negative effects on placentation, when they bind to the trophoblast, reducing their capacity for invasion, and proinflammatory effects, such as complement activation and neutrophil recruitment, contributing to placental insufficiency, restricted intrauterine growth, and fetal loss. In relation to thrombosis, APS results in a diffuse thrombotic diathesis, with global and diffuse dysregulation of the homeostatic balance. Knowing the pathophysiology of APS, which is closely linked to female infertility, is essential for new therapeutic approaches, specialized in immunomodulation and inflammatory signaling pathways, to provide important advances in its treatment.
ISSN:0100-7203
1806-9339
1806-9339
DOI:10.1055/s-0039-1697982