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The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells

Servicio de Inmunología and Unidad de Investigación (EO, LD-P, AC-C, JAB); Servicio de Hematología, Hospital Universitario Puerta del Mar, Cádiz, Spain (JM); Servicio de Hematología, Hospital Universitario de Puerto Real, Cádiz, Spain (AP); Servicio de Hematología, Hospital Punta Europa, Algeciras,...

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Published in:Haematologica (Roma) 2007-03, Vol.92 (3), p.349-356
Main Authors: Ocana, Esther, Delgado-Perez, Luis, Campos-Caro, Antonio, Munoz, Juan, Paz, Antonio, Franco, Rafael, Brieva, Jose A
Format: Article
Language:English
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Summary:Servicio de Inmunología and Unidad de Investigación (EO, LD-P, AC-C, JAB); Servicio de Hematología, Hospital Universitario Puerta del Mar, Cádiz, Spain (JM); Servicio de Hematología, Hospital Universitario de Puerto Real, Cádiz, Spain (AP); Servicio de Hematología, Hospital Punta Europa, Algeciras, Cádiz, Spain (RF) Correspondence: José A. Brieva, Servicio de Inmunología, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009 Cádiz, Spain. E mail: josea.brieva.sspa{at}juntadeandalucia.es Background and Objectives: Chemokine receptors are involved in tumor progression and several of these receptors, including CXCR3, are expressed by chronic lymphocytic leukemia (CLL) B cells. This study was aimed to examine a possible relationship between CXCR3 expression in CLL and the clinical evolution of the disease. Design and Methods: Using flow activated cell sorting (FACS), we analyzed the level of expression of CXCR3 on blood CLL B cells from 76 consecutive patients. The results were correlated with CD38 expression, IgV H gene status and clinical outcome. Results: CXCR3, measured as mean fluorescence intensity (MFI), was unimodally expressed by blood tumor cells at various levels (range, 3.5 to 232.3) but levels within individual patients were remarkably stable over time. Low CXCR3 expression by CLL B cells was strongly associated with Rai disease stages III and IV ( p
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.10649