Correlation between Chest Computed Tomography Score and Laboratory Biomarkers in the Risk Stratification of COVID-19 Patients Admitted to the Emergency Department

• Published in: Diagnostics (Basel) 2023-08, Vol.13 (17), p.2829
• Main Authors: D’Agostini, Cartesio, Legramante, Jacopo M, Minieri, Marilena, Di Lecce, Vito N, Lia, Maria Stella, Maurici, Massimo, Simonelli, Ilaria, Ciotti, Marco, Paganelli, Carla, Terrinoni, Alessandro, Giovannelli, Alfredo, Pieri, Massimo, Gallù, Mariacarla, Dell’Olio, Vito, Prezioso, Carla, Limongi, Dolores, Bernardini, Sergio, Orlacchio, Antonio
• Format: Article
• Language: English
• Subjects: Automation; Biomarkers; Chronic obstructive pulmonary disease; COVID-19; CT imaging; CT score; Diagnosis; emergency department; Emergency medical care; Emergency service; Epidemiology; Ethylenediaminetetraacetic acid; Health aspects; Hospitals; Infection; Infections; Laboratories; laboratory biomarkers; Medical research; Medicine, Experimental; Mortality; MR-proadrenomedullin; Patients; Peptides; Pneumonia; Proteins; Sepsis; Severe acute respiratory syndrome coronavirus 2; Software; Taiwan; Tomography; Variables; Ventilators
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics13172829

Background: It has been reported that mid-regional proadrenomedullin (MR-proADM) could be considered a useful tool to stratify the mortality risk in COVID-19 patients upon admission to the emergency department (ED). During the COVID-19 outbreak, computed tomography (CT) scans were widely used for their excellent sensitivity in diagnosing pneumonia associated with SARS-CoV-2 infection. However, the possible role of CT score in the risk stratification of COVID-19 patients upon admission to the ED is still unclear. Aim: The main objective of this study was to assess if the association of the CT findings alone or together with MR-proADM results could ameliorate the prediction of in-hospital mortality of COVID-19 patients at the triage. Moreover, the hypothesis that CT score and MR-proADM levels together could play a key role in predicting the correct clinical setting for these patients was also evaluated. Methods: Epidemiological, demographic, clinical, laboratory, and outcome data were assessed and analyzed from 265 consecutive patients admitted to the triage of the ED with a SARS-CoV-2 infection. Results and conclusions: The accuracy results by AUROC analysis and statistical analysis demonstrated that CT score is particularly effective, when utilized together with the MR-proADM level, in the risk stratification of COVID-19 patients admitted to the ED, thus helping the decision-making process of emergency physicians and optimizing the hospital resources.