Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity

• Published in: Molecules (Basel, Switzerland) Switzerland), 2017-04, Vol.22 (4), p.515
• Main Authors: Zhong, Cheng, Hu, Deng, Hou, Lian-Bing, Song, Lu-Yao, Zhang, Ying-Jun, Xie, Yang, Tian, Li-Wen
• Format: Article
• Language: English
• Subjects: anti-inflammatory activity; Anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Cell Line; Chemical compounds; Chromatography; Cytokines - biosynthesis; Flavonoids; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Humans; IL-1β; Inflammation; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Molecular Structure; Organic chemistry; Phenolic compounds; Phenols; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Rhizome - chemistry; Rhizomes; Smilax - chemistry; Smilax china
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22040515

A new triflavanoid, kandelin B-5 ( ), was isolated from the rhizomes of L., together with six known phenylpropanoid substituted flavan-3-ols ( - ), nine flavonoids ( - ), two stilbenoids ( , ), and two other compounds ( , ). The structure of compound was determined on the basis of 1D, 2D NMR and HR-ESI-MS data, as well as chemical method. Compounds - , - , , , and were evaluated for anti-inflammatory activity. Only compounds , and showed slightly IL-1β expression inhibitory activities on LPS induced THP-1 cells, with inhibition rate of 15.8%, 37.3%, and 35.8%, respectively, at concentration of 50 μg/mL.