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Different care mode alter composition and function of gut microbiota in cerebral palsy children
Specialized care is essential for the recovery of children with cerebral palsy (CP). This study investigates how different care modes impact the gut microbiota. Fecal samples from 32 children were collected, among whom those cared for by family ( = 21) were selected as the observation group, and tho...
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| Published in: | Frontiers in pediatrics 2024-08, Vol.12, p.1440190 |
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| container_start_page | 1440190 |
| container_title | Frontiers in pediatrics |
| container_volume | 12 |
| creator | Lyu, Jinli Zhang, Xiaowei Xiong, Shenghua Wu, Hui Han, Jing Xie, Yongjie Qiu, Feifeng Yang, Zhenyu Huang, Congfu |
| description | Specialized care is essential for the recovery of children with cerebral palsy (CP). This study investigates how different care modes impact the gut microbiota.
Fecal samples from 32 children were collected, among whom those cared for by family (
= 21) were selected as the observation group, and those cared for by children's welfare institutions (
= 11) were selected as the control group (registration number of LGFYYXLL-024). The gut microbiota profiles were analyzed.
There was no significant difference in the α-diversity of the gut microbiota and the abundance at the phylum level. However, at the genus level, the observation group showed a significant increase in the abundance of butyrate-producing bacteria
and
(
|
| doi_str_mv | 10.3389/fped.2024.1440190 |
| format | article |
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Fecal samples from 32 children were collected, among whom those cared for by family (
= 21) were selected as the observation group, and those cared for by children's welfare institutions (
= 11) were selected as the control group (registration number of LGFYYXLL-024). The gut microbiota profiles were analyzed.
There was no significant difference in the α-diversity of the gut microbiota and the abundance at the phylum level. However, at the genus level, the observation group showed a significant increase in the abundance of butyrate-producing bacteria
and
(
< 0.05), and a significant decrease in the abundance of opportunistic pathogens
,
cluster IV,
, and
(
< 0.05). Additionally, lipid metabolism, carbohydrate metabolism, transcription, cellular processes and signaling, and membrane transport were significantly upregulated in the observation group. Lipid metabolism was positively correlated with
and
, indicating a positive impact of the family-centered care mode on bacterial metabolism processes.
This study highlights that the family-centered care mode had a positive impact on the composition and function of the gut microbiota. The study provides valuable insights into the relationship between care mode and gut microbiota, which can inspire the development of interventions for cerebral palsy.</description><identifier>ISSN: 2296-2360</identifier><identifier>EISSN: 2296-2360</identifier><identifier>DOI: 10.3389/fped.2024.1440190</identifier><identifier>PMID: 39239470</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>16S rRNA sequence ; cerebral palsy ; family-centered care mode ; Gut microbiota ; Pediatrics ; welfare-centered care mode</subject><ispartof>Frontiers in pediatrics, 2024-08, Vol.12, p.1440190</ispartof><rights>2024 Lyu, Zhang, Xiong, Wu, Han, Xie, Qiu, Yang and Huang.</rights><rights>2024 Lyu, Zhang, Xiong, Wu, Han, Xie, Qiu, Yang and Huang. 2024 Lyu, Zhang, Xiong, Wu, Han, Xie, Qiu, Yang and Huang</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374594/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374594/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39239470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyu, Jinli</creatorcontrib><creatorcontrib>Zhang, Xiaowei</creatorcontrib><creatorcontrib>Xiong, Shenghua</creatorcontrib><creatorcontrib>Wu, Hui</creatorcontrib><creatorcontrib>Han, Jing</creatorcontrib><creatorcontrib>Xie, Yongjie</creatorcontrib><creatorcontrib>Qiu, Feifeng</creatorcontrib><creatorcontrib>Yang, Zhenyu</creatorcontrib><creatorcontrib>Huang, Congfu</creatorcontrib><title>Different care mode alter composition and function of gut microbiota in cerebral palsy children</title><title>Frontiers in pediatrics</title><addtitle>Front Pediatr</addtitle><description>Specialized care is essential for the recovery of children with cerebral palsy (CP). This study investigates how different care modes impact the gut microbiota.
Fecal samples from 32 children were collected, among whom those cared for by family (
= 21) were selected as the observation group, and those cared for by children's welfare institutions (
= 11) were selected as the control group (registration number of LGFYYXLL-024). The gut microbiota profiles were analyzed.
There was no significant difference in the α-diversity of the gut microbiota and the abundance at the phylum level. However, at the genus level, the observation group showed a significant increase in the abundance of butyrate-producing bacteria
and
(
< 0.05), and a significant decrease in the abundance of opportunistic pathogens
,
cluster IV,
, and
(
< 0.05). Additionally, lipid metabolism, carbohydrate metabolism, transcription, cellular processes and signaling, and membrane transport were significantly upregulated in the observation group. Lipid metabolism was positively correlated with
and
, indicating a positive impact of the family-centered care mode on bacterial metabolism processes.
This study highlights that the family-centered care mode had a positive impact on the composition and function of the gut microbiota. The study provides valuable insights into the relationship between care mode and gut microbiota, which can inspire the development of interventions for cerebral palsy.</description><subject>16S rRNA sequence</subject><subject>cerebral palsy</subject><subject>family-centered care mode</subject><subject>Gut microbiota</subject><subject>Pediatrics</subject><subject>welfare-centered care mode</subject><issn>2296-2360</issn><issn>2296-2360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkUtLNTEMhosoKuoPcCNdujnH3jtdiXgHwY2uS6aXY2VmOl9nRvDfW9RPNJukSXjeJkHomJI15405i2Pwa0aYWFMhCDVkC-0zZtSKcUW2f8V76GiaXkk1o4mkchftccO4EZrsI3uVYgwlDDN2UALusw8YujkU7HI_5inNKQ8YBo_jMrjPR454s8y4T67kNuUZcBqwq5C2QIdH6KZ37F5S5yv2EO3EmghH3_4APd9cP13erR4eb-8vLx5WnhM1r3wg1EkntVdKga5fi9EpGSi00sWGRcmUcBxAASNe6dZwME1LvW5ViN7zA3T_xfUZXu1YUg_l3WZI9jORy8ZCmZPrgtVSeqJYY6RhwlBoRKu1BB-coF5QVlnnX6xxafvgXV1OHewP9G9lSC92k98spVwLaUQlnH4TSv63hGm2fZpc6DoYQl4myympOpQ1urae_Bb7Ufl_Iv4BU3yWYw</recordid><startdate>20240822</startdate><enddate>20240822</enddate><creator>Lyu, Jinli</creator><creator>Zhang, Xiaowei</creator><creator>Xiong, Shenghua</creator><creator>Wu, Hui</creator><creator>Han, Jing</creator><creator>Xie, Yongjie</creator><creator>Qiu, Feifeng</creator><creator>Yang, Zhenyu</creator><creator>Huang, Congfu</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240822</creationdate><title>Different care mode alter composition and function of gut microbiota in cerebral palsy children</title><author>Lyu, Jinli ; Zhang, Xiaowei ; Xiong, Shenghua ; Wu, Hui ; Han, Jing ; Xie, Yongjie ; Qiu, Feifeng ; Yang, Zhenyu ; Huang, Congfu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d306t-de01c5c57d666a7470ffc65e1ab5cf82f5264c3aa6a20d67b93a98b1d7b6efdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>16S rRNA sequence</topic><topic>cerebral palsy</topic><topic>family-centered care mode</topic><topic>Gut microbiota</topic><topic>Pediatrics</topic><topic>welfare-centered care mode</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyu, Jinli</creatorcontrib><creatorcontrib>Zhang, Xiaowei</creatorcontrib><creatorcontrib>Xiong, Shenghua</creatorcontrib><creatorcontrib>Wu, Hui</creatorcontrib><creatorcontrib>Han, Jing</creatorcontrib><creatorcontrib>Xie, Yongjie</creatorcontrib><creatorcontrib>Qiu, Feifeng</creatorcontrib><creatorcontrib>Yang, Zhenyu</creatorcontrib><creatorcontrib>Huang, Congfu</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyu, Jinli</au><au>Zhang, Xiaowei</au><au>Xiong, Shenghua</au><au>Wu, Hui</au><au>Han, Jing</au><au>Xie, Yongjie</au><au>Qiu, Feifeng</au><au>Yang, Zhenyu</au><au>Huang, Congfu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different care mode alter composition and function of gut microbiota in cerebral palsy children</atitle><jtitle>Frontiers in pediatrics</jtitle><addtitle>Front Pediatr</addtitle><date>2024-08-22</date><risdate>2024</risdate><volume>12</volume><spage>1440190</spage><pages>1440190-</pages><issn>2296-2360</issn><eissn>2296-2360</eissn><abstract>Specialized care is essential for the recovery of children with cerebral palsy (CP). This study investigates how different care modes impact the gut microbiota.
Fecal samples from 32 children were collected, among whom those cared for by family (
= 21) were selected as the observation group, and those cared for by children's welfare institutions (
= 11) were selected as the control group (registration number of LGFYYXLL-024). The gut microbiota profiles were analyzed.
There was no significant difference in the α-diversity of the gut microbiota and the abundance at the phylum level. However, at the genus level, the observation group showed a significant increase in the abundance of butyrate-producing bacteria
and
(
< 0.05), and a significant decrease in the abundance of opportunistic pathogens
,
cluster IV,
, and
(
< 0.05). Additionally, lipid metabolism, carbohydrate metabolism, transcription, cellular processes and signaling, and membrane transport were significantly upregulated in the observation group. Lipid metabolism was positively correlated with
and
, indicating a positive impact of the family-centered care mode on bacterial metabolism processes.
This study highlights that the family-centered care mode had a positive impact on the composition and function of the gut microbiota. The study provides valuable insights into the relationship between care mode and gut microbiota, which can inspire the development of interventions for cerebral palsy.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>39239470</pmid><doi>10.3389/fped.2024.1440190</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Frontiers in pediatrics, 2024-08, Vol.12, p.1440190 |
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| language | eng |
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| source | PubMed Central |
| subjects | 16S rRNA sequence cerebral palsy family-centered care mode Gut microbiota Pediatrics welfare-centered care mode |
| title | Different care mode alter composition and function of gut microbiota in cerebral palsy children |
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