A Prospective Study of Male Depression, Psychotropic Medication Use, and Fecundability

We examined the associations of male depression and psychotropic medication use with fecundability in a North American preconception cohort study (2013–2020). Men aged ≥21 years completed a baseline questionnaire with questions on history of diagnosed depression, the Major Depression Inventory (MDI)...

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Bibliographic Details
Published in:American journal of men's health 2022-01, Vol.16 (1), p.15579883221075520-15579883221075520
Main Authors: Yland, Jennifer J., McKinnon, Craig J., Hatch, Elizabeth E., Eisenberg, Michael L., Nillni, Yael I., Rothman, Kenneth J., Wise, Lauren A.
Format: Article
Language:English
Subjects:
Adult
Antidepressants
Cohort Studies
Depression - drug therapy
Depression - epidemiology
Female
Fertility
Fertilization
Humans
Male
Mens health
Mental depression
Original
Pregnancy
Prospective Studies
Psychotropic drugs
Reproductive health
Young Adult
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Summary:We examined the associations of male depression and psychotropic medication use with fecundability in a North American preconception cohort study (2013–2020). Men aged ≥21 years completed a baseline questionnaire with questions on history of diagnosed depression, the Major Depression Inventory (MDI), and psychotropic medication use. Pregnancy status was updated via bimonthly female follow-up questionnaires until pregnancy or 12 menstrual cycles, whichever occurred first. Analyses were restricted to 2,398 couples attempting conception for ≤6 menstrual cycles at entry. We fit proportional probabilities models to estimate fecundability ratios (FRs) and 95% confidence intervals (CIs), adjusting for age (male and female), education, (male and female), race/ethnicity, physical activity, alcohol intake, body mass index, smoking, and having previously impregnated a partner. Nearly 12% of participants reported a depression diagnosis; 90.6% had low depressive symptoms (MDI
ISSN:1557-9883
1557-9891
DOI:10.1177/15579883221075520