Multiple adrenocortical steroid response to administration of exogenous adrenocorticotropic hormone to hospitalized foals

Background The hypothalamic‐pituitary‐adrenal axis regulates the response to sepsis‐associated stress. Relative adrenal insufficiency or adrenocorticotropic hormone (ACTH):cortisol imbalance, defined as a poor cortisol response to administration of ACTH, is common and associated with death in hospit...

Full description

Saved in:
Bibliographic Details
Published in:Journal of veterinary internal medicine 2019-07, Vol.33 (4), p.1766-1774
Main Authors: Dembek, Katarzyna A., Johnson, Lindsey M., Timko, Kathryn J., Minuto, Jillian S., Hart, Kelsey A., Barr, Bonnie S., Toribio, Ramiro E.
Format: Article
Language:English
Subjects:
17-alpha-Hydroxyprogesterone - blood
Adrenal Cortex Hormones - blood
Adrenal glands
adrenal insufficiency
Adrenocorticotropic hormone
Adrenocorticotropic Hormone - administration & dosage
Adrenocorticotropic Hormone - pharmacology
Aldosterone
Androstenedione
Animals
Animals, Newborn
Area Under Curve
Biochemistry
Biodegradation
Cluster Analysis
Cortisol
Critical Illness
EQUID
equine
Female
Hormones
Horse Diseases - blood
Horse Diseases - drug therapy
Horse Diseases - mortality
Horses
Hospitalization
Hospitals
Hypothalamus
Illnesses
Immunoassays
Immunoglobulins
Internal medicine
Laboratories
Male
Medical prognosis
Metabolism
Pituitary
Pregnenolone
Progesterone
Prognosis
Prospective Studies
Sepsis
Sepsis - drug therapy
Sepsis - veterinary
Steroid hormones
Steroids
Stimulation
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The hypothalamic‐pituitary‐adrenal axis regulates the response to sepsis‐associated stress. Relative adrenal insufficiency or adrenocorticotropic hormone (ACTH):cortisol imbalance, defined as a poor cortisol response to administration of ACTH, is common and associated with death in hospitalized foals. However, information on other adrenal steroid response to ACTH stimulation in sick foals is minimal. Objective To investigate the response of multiple adrenocortical steroids to administration of ACTH in foals. Animals Hospitalized (n = 34) and healthy (n = 13) foals. Methods In this prospective study, hospitalized foals were categorized into 2 groups using cluster analysis based on adrenal steroids response to ACTH stimulation: Cluster 1 (n = 11) and Cluster 2 (n = 23). After baseline blood sample collection, foals received 10 μg of ACTH with additional samples collected at 30 and 90 minutes after ACTH. Steroid and ACTH concentrations were determined by immunoassays. The area under the curve (AUC) and Delta0‐30 were calculated for each hormone. Results The AUC for cortisol, aldosterone, androstenedione, pregnenolone, 17α‐OH‐progesterone, and progesterone were higher in critically ill (Cluster 1) compared to healthy foals (P
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.15527