Physical compatibility of Xuebijing injection with 53 intravenous drugs during simulated Y-site administration

Xuebijing injection (XBJ) is a commonly used herbal medicine injection in China. However, the physical compatibility of XBJ with other intravenous drugs remains unclear. The purpose of this research is to evaluate physical compatibility of Xuebijing injection (XBJ) with 53 intravenous drugs (includi...

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Bibliographic Details
Published in:PloS one 2024-03, Vol.19 (3), p.e0299694
Main Authors: Tong, Tong, Li, Peifang, Ding, Haiwen, Huang, Ying, Liu, Sheng
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Drugs, Chinese Herbal
Etoposide
Health aspects
Infusions, Intravenous
Injections, Intravenous
Medicine, Botanic
Medicine, Chinese
Medicine, Herbal
Pantoprazole
Sulbactam
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Summary:Xuebijing injection (XBJ) is a commonly used herbal medicine injection in China. However, the physical compatibility of XBJ with other intravenous drugs remains unclear. The purpose of this research is to evaluate physical compatibility of Xuebijing injection (XBJ) with 53 intravenous drugs (including 31 Chinese medicine injections and 22 chemicals) during simulated Y-site administration. Y-site administration was simulated in vitro by admixing 0.33 ml/ml XBJ with an equal volume of other diluted 53 intravenous drugs, respectively. Physical compatibility including visual inspection, Tyndall beam, particle limits, turbidity, pH, chromacity value, spectroscopic absorption of 550 nm and 420 nm (A550 nm and A420 nm) were observed and assessed at 0, 1, 2, and 4 h. Physical compatibility was defined as all solutions with no color changes, no gas evolution, particulate formation and no Tyndall beam within 4 hours, turbidity changes
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0299694