Advances in Nanodelivery of Green Tea Catechins to Enhance the Anticancer Activity

Cancer is one of the leading causes of death globally. A variety of phenolic compounds display preventative and therapeutic effects against cancers. Green teas are rich in phenolics. Catechins are the most dominant phenolic component in green teas. Studies have shown that catechins have anticancer a...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-05, Vol.26 (11), p.3301
Main Authors: Jiang, Yike, Jiang, Ziyi, Ma, Lan, Huang, Qingrong
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-Infective Agents - pharmacology
Anti-Inflammatory Agents - pharmacology
anticancer activity
Antineoplastic Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Antitumor activity
Apoptosis
Bioavailability
Cancer
Catechin
Catechin - chemistry
catechins
Cell Cycle - drug effects
Cell Proliferation
DNA methylation
Drug Carriers
Drug Delivery Systems
Enzymes
Gastrointestinal Microbiome - drug effects
Green tea
Homeostasis
Humans
Lipids - chemistry
Mice
Molecular modelling
nanodelivery system
Nanomedicine - methods
Nanomedicine - trends
Neoplasm Metastasis - drug therapy
Neoplasms - drug therapy
Oxidative stress
Phenol - chemistry
Phenolic compounds
Phenols
Polyphenols
Proteins
Review
Tea
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Summary:Cancer is one of the leading causes of death globally. A variety of phenolic compounds display preventative and therapeutic effects against cancers. Green teas are rich in phenolics. Catechins are the most dominant phenolic component in green teas. Studies have shown that catechins have anticancer activity in various cancer models. The anticancer activity of catechins, however, may be compromised due to their low oral bioavailability. Nanodelivery emerges as a promising way to improve the oral bioavailability and anticancer activity of catechins. Research in this area has been actively conducted in recent decades. This review provides the molecular mechanisms of the anticancer effects of catechins, the factors that limit the oral bioavailability of catechins, and the latest advances of delivering catechins using nanodelivery systems through different routes to enhance their anticancer activity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26113301