Preparation of Fe3O4/SiO2/TiO2/CeVO4 Nanocomposites: Investigation of Photocatalytic Effects on Organic Pollutants, Bacterial Environments, and New Potential Therapeutic Candidate Against Cancer Cells

The new nanocomposite with various molar ratios along with magnetic properties was fabricated via precipitation (assisted by ultrasonic) procedure. The photocatalytic effects of methylene blue (∼90% degradation for optimized sample in 100 min) for finding the optimized sample performed under visible...

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Bibliographic Details
Published in:Frontiers in pharmacology 2020-03, Vol.11
Main Authors: Marsooli, Mohammad Amin, Rahimi-Nasrabadi, Mahdi, Fasihi-Ramandi, Mahdi, Adib, Kourosh, Eghbali-Arani, Mohammad, Ahmadi, Farhad, Sohouli, Esmail, Sobhani nasab, Ali, Mirhosseini, Seyed Ali, Gangali, Mohamad Reza, Ehrlich, Hermann, Joseph, Yvonne
Format: Article
Language:English
Subjects:
anti-cancer
Fe3O4/SiO2/TiO2
Fe3O4/SiO2/TiO2/CeVO4
nanocomposites
Pharmacology
photo-antibacterial
photocatalytic
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Summary:The new nanocomposite with various molar ratios along with magnetic properties was fabricated via precipitation (assisted by ultrasonic) procedure. The photocatalytic effects of methylene blue (∼90% degradation for optimized sample in 100 min) for finding the optimized sample performed under visible light irradiation. Moreover, the photo-antibacterial impacts of bacteria culture environments were found with an optimized sample that had effective destruction of bacteria in comparison to control group. The cytotoxicity properties of panc1 cells and magnetic behaviors of the obtained nanomaterials were evaluated and its IC50 was about 500 mg/L. As an initial step, the structural, morphological and magnetic characteristics of the fabricated nanocomposites were evaluated by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray (EDX) and MAP, UV-visible diffuse reflectance spectroscopy (DRS), and vibrating sample magnetometry (VSM) approaches. Based on SEM results, the size of nanoparticles in fabricated nanocomposite was nearly 50–70 nm for Fe 3 O 4 /SiO 2 /TiO 2 and 80–100 nm for Fe 3 O 4 /SiO 2 /TiO 2 /CeVO 4 . XRD results showed that desired nanocomposites were truly synthesized without any impurities.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2020.00192