Microbiota transplantation: concept, methodology and strategy for its modernization

Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infecti...

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Bibliographic Details
Published in:Protein & cell 2018-05, Vol.9 (5), p.462-473
Main Authors: Zhang, Faming, Cui, Bota, He, Xingxiang, Nie, Yuqiang, Wu, Kaichun, Fan, Daiming, Study Group, FMT-standardization
Format: Article
Language:English
Subjects:
bacteria
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cirrhosis
Clostridium difficile
Developmental Biology
Diabetes mellitus
Fecal microflora
Human Genetics
inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Life Sciences
Liver cancer
Liver cirrhosis
Liver diseases
microbiome
Microbiota
perspectives
Protein Science
Review
selective microbiota transplantation
selective microbiota transplantation
Stem Cells
step-up fecal microbiota transplantation
Transplantation
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Summary:Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gutbrain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future. Here, we review the changing concept of microbiota transplantation from FMT to selective microbiota transplantation, methodology development of FMT and stepup FMT strategy based on literature and state experts' perspectives.
ISSN:1674-800X
1674-8018
DOI:10.1007/s13238-018-0541-8