Treatment Results for Stage III Laryngeal Cancer: Analysis of a Populational Database Using Propensity Scores

Abstract Introduction  Treatment of stage III laryngeal cancer suffered a major paradigm change with surgery being substituted by radiation therapy with chemotherapy. Objective  To evaluate the oncological outcome of different treatment modalities for stage III laryngeal cancer using a population da...

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Bibliographic Details
Published in:International Archives of Otorhinolaryngology 2022-07, Vol.26 (3), p.e370-e379
Main Authors: Köhler, Hugo Fontan, Carvalho, Genival Barbosa de, Kowalski, Luiz Paulo
Format: Article
Language:English
Subjects:
laryngeal neoplasms
Original Research
OTORHINOLARYNGOLOGY
prognosis
propensity score
radiotherapy
surgery
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Summary:Abstract Introduction  Treatment of stage III laryngeal cancer suffered a major paradigm change with surgery being substituted by radiation therapy with chemotherapy. Objective  To evaluate the oncological outcome of different treatment modalities for stage III laryngeal cancer using a population database. Methods  A population database representing patients treated in the state of São Paulo, Brazil, was analyzed. Demographic, clinical and treatment variables were included, and the outcomes of interest were disease-specific and overall survival. Propensity score with nearest neighbor matching was used to compensate for imbalances in treatment groups. Results  We retrieved data from 1,804 patients. In multivariate analysis, age, female gender, payment source, clinical N stage (cN) stages, and treatment modality were significant for disease-specific and overall survival. Patients submitted to surgery treatment had a significantly better disease-specific ( p  
ISSN:1809-9777
1809-4864
1809-4864
DOI:10.1055/s-0041-1726042