Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is know...

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Published in:Frontiers in behavioral neuroscience 2014-04, Vol.8, p.133-133
Main Authors: Lopatina, Olga, Yoshihara, Toru, Nishimura, Tomoko, Zhong, Jing, Akther, Shirin, Fakhrul, Azam A K M, Liang, Mingkun, Higashida, Chiharu, Sumi, Kohei, Furuhara, Kazumi, Inahata, Yuki, Huang, Jian-Jung, Koizumi, Keita, Yokoyama, Shigeru, Tsuji, Takahiro, Petugina, Yulia, Sumarokov, Andrei, Salmina, Alla B, Hashida, Koji, Kitao, Yasuko, Hori, Osamu, Asano, Masahide, Kitamura, Yoji, Kozaka, Takashi, Shiba, Kazuhiro, Zhong, Fangfang, Xie, Min-Jue, Sato, Makoto, Ishihara, Katsuhiko, Higashida, Haruhiro
Format: Article
Language:English
Subjects:
ADP-ribosyl cyclase
Aging
Amygdala
Anxiety
Bone marrow
Brain research
Bst-1
BST1 gene
c-Fos protein
emotion-related behavior
Glycosylphosphatidylinositol
Immunoreactivity
Intestine
Lymphocytes B
Medical research
Memory
Mental depression
Movement disorders
Nervous system
Neurodegenerative diseases
Neuroscience
non-motor symptoms
Oxytocin
Parkinson's disease
Rheumatoid arthritis
Risk factors
Science
Signal transduction
Social Behavior
Stem cell transplantation
Stem cells
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Summary:CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. CD157 (-/-) mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157 (-/-) mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2014.00133