Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus

Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus w...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2015-07, Vol.20 (7), p.12500-12511
Main Authors: Cui, Yanmei, Taniguchi, Shoko, Kuroda, Teruo, Hatano, Tsutomu
Format: Article
Language:English
Subjects:
Acetates
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
bakuflavanone
bakuisoflavone
Chalcones - chemistry
Chalcones - isolation & purification
Chalcones - pharmacology
Chromatography
Chromatography, Gel
Dentistry
Flavonoids
Flowers & plants
Fruit - chemistry
methicillin-resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - growth & development
Microbial Sensitivity Tests
Molecular Structure
Pharmaceutical sciences
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
Psoralea - chemistry
Psoralea corylifolia
Solvents
Staphylococcus infections
Structure-Activity Relationship
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Summary:Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%-16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules200712500