Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy

Background The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity. Tumor-infiltrating CD1a.sup.+ DCs have been reported to be associated with clinical outcomes in carcinomas of various o...

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Bibliographic Details
Published in:BMC cancer 2021-08, Vol.21 (1), p.1-973, Article 973
Main Authors: Minesaki, Akimichi, Kai, Keita, Kuratomi, Yuichiro, Aishima, Shinichi
Format: Article
Language:English
Subjects:
Antigens
Cancer therapies
Carcinoma
Care and treatment
CD1a
CD8 antigen
Cellular proteins
Chemotherapy
Cytotoxicity
Dendritic cell
Dendritic cells
Development and progression
Gene expression
Genetic aspects
Health aspects
Immunohistochemistry
Infiltration
Laryngeal cancer
Laryngectomy
Lymphocytes T
Medical prognosis
Metastases
Metastasis
Multivariate analysis
Patient outcomes
Patients
Prognosis
Radiation therapy
Surgery
Thyroid gland
Tumors
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Summary:Background The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity. Tumor-infiltrating CD1a.sup.+ DCs have been reported to be associated with clinical outcomes in carcinomas of various organs, but the clinical impact of CD1a.sup.+ DCs in laryngeal cancer remains to be unequivocally established. Methods We retrospectively analyzed the cases of 57 patients with Stage III or IV laryngeal cancer who underwent a total laryngectomy. Immunohistochemistry detection of CD1a, S100 and CD8 was performed on representative resected specimens. CD1a.sup.+ DCs, S100.sup.+ DCs and CD8.sup.+ cytotoxic T-lymphocytes (CTLs) were evaluated, and the cases divided into high and low groups according to the cut-off of the median values for each of these 3 parameters. Results Compared to the CD1a-low group, the CD1a-high group had more advanced cases and showed significantly worse disease-specific survival (DSS) (P = 0.008) and overall survival (OS) (P = 0.032). The analyses of S100 DCs and CD8.sup.+ CTLs revealed no significant impact on clinical outcomes. However, multivariate analysis revealed that infiltration of CD1a.sup.+ DCs was an independent unfavorable prognostic factor for both DSS (P = 0.009) and OS (P = 0.013). Conclusions Our results demonstrated that the infiltration of CD1a.sup.+ DCs was associated with unfavorable clinical outcomes in patients with advanced laryngeal cancer who underwent a total laryngectomy as the initial treatment. Keywords: Laryngeal cancer, CD1a, Dendritic cell, Prognosis, Immunohistochemistry
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-021-08715-6