Circuit dynamics of the olfactory pathway during olfactory learning

The olfactory system plays crucial roles in perceiving and interacting with their surroundings. Previous studies have deciphered basic odor perceptions, but how information processing in the olfactory system is associated with learning and memory is poorly understood. In this review, we summarize re...

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Bibliographic Details
Published in:Frontiers in neural circuits 2024-07, Vol.18, p.1437575
Main Authors: Zhang, Yutian J, Lee, Jason Y, Igarashi, Kei M
Format: Article
Language:English
Subjects:
Animals
Entorhinal Cortex - physiology
hippocampus
Humans
lateral entorhinal cortex (LEC)
Learning - physiology
Mice
olfactory
Olfactory Bulb - physiology
olfactory cortex
Olfactory Cortex - physiology
Olfactory learning
Olfactory Pathways - physiology
Olfactory Perception - physiology
Smell - physiology
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Summary:The olfactory system plays crucial roles in perceiving and interacting with their surroundings. Previous studies have deciphered basic odor perceptions, but how information processing in the olfactory system is associated with learning and memory is poorly understood. In this review, we summarize recent studies on the anatomy and functional dynamics of the mouse olfactory learning pathway, focusing on how neuronal circuits in the olfactory bulb (OB) and olfactory cortical areas integrate odor information in learning. We also highlight in vivo evidence for the role of the lateral entorhinal cortex (LEC) in olfactory learning. Altogether, these studies demonstrate that brain regions throughout the olfactory system are critically involved in forming and representing learned knowledge. The role of olfactory areas in learning and memory, and their susceptibility to dysfunction in neurodegenerative diseases, necessitate further research.
ISSN:1662-5110
1662-5110
DOI:10.3389/fncir.2024.1437575