Motor actions are spatially organized in motor and dorsal premotor cortex

Frontal motor areas are central to controlling voluntary movements. In non-human primates, the motor areas contain independent, somatotopic, representations of the forelimb (i.e., motor maps). But are the neural codes for actions spatially organized within those forelimb representations? Addressing...

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Bibliographic Details
Published in:eLife 2023-10, Vol.12
Main Authors: Chehade, Nicholas G, Gharbawie, Omar A
Format: Article
Language:English
Subjects:
Animals
Arm
Blood vessels
Brain Mapping
Cortex (motor)
Cortex (premotor)
Electric Stimulation
Electromyography
Forelimb - physiology
Grasping
Limbs
Macaca
Mapping
microstimulation
motor behavior
Motor Cortex - physiology
motor system
Neuroimaging
Neurons
Neuroscience
optical imaging
reach
somatosensory system
Structure-function relationships
Citations: Items that this one cites
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Summary:Frontal motor areas are central to controlling voluntary movements. In non-human primates, the motor areas contain independent, somatotopic, representations of the forelimb (i.e., motor maps). But are the neural codes for actions spatially organized within those forelimb representations? Addressing this question would provide insight into the poorly understood structure-function relationships of the cortical motor system. Here, we tackle the problem using high-resolution optical imaging and motor mapping in motor (M1) and dorsal premotor (PMd) cortex. Two macaque monkeys performed an instructed reach-to-grasp task while cortical activity was recorded with intrinsic signal optical imaging (ISOI). The spatial extent of activity in M1 and PMd was then quantified in relation to the forelimb motor maps, which we obtained from the same hemisphere with intracortical microstimulation. ISOI showed that task-related activity was concentrated in patches that collectively overlapped
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.83196