Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury

Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the development and resolution of edema following traumatic brain injury (TBI). This review examines the alterations in AQP expression and localization post-injury, exploring their effects...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (12), p.6553
Main Authors: Czyżewski, Wojciech, Litak, Jakub, Sobstyl, Jan, Mandat, Tomasz, Torres, Kamil, Staśkiewicz, Grzegorz
Format: Article
Language:English
Subjects:
Animals
AQP1
AQP4
AQP9
aquaporin
Aquaporin 4 - metabolism
Aquaporins
Aquaporins - metabolism
B cells
Blood vessels
Brain
Brain - metabolism
brain edema
Brain Edema - etiology
Brain Edema - metabolism
Brain Injuries, Traumatic - metabolism
Brain research
Cerebrospinal fluid
Disability
Edema
Homeostasis
Humans
Hydrodynamics
Injuries
Intracranial pressure
Localization
Nervous system
Neurophysiology
Pathology
Review
Spinal cord
TBI
Traumatic brain injury
Water
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Summary:Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the development and resolution of edema following traumatic brain injury (TBI). This review examines the alterations in AQP expression and localization post-injury, exploring their effects on brain edema and overall injury outcomes. We discuss the underlying molecular mechanisms regulating AQP expression, highlighting potential therapeutic strategies to modulate AQP function. These insights provide a comprehensive understanding of AQPs in TBI and suggest novel approaches for improving clinical outcomes through targeted interventions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25126553