Innate Immunity and Neuroinflammation

Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be...

Full description

Saved in:
Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.1076-1094-096
Main Authors: Shastri, Abhishek, Bonifati, Domenico Marco, Kishore, Uday
Format: Article
Language:English
Subjects:
Animals
Astrocytes - cytology
Astrocytes - pathology
Central Nervous System - pathology
Complement System Proteins - physiology
Humans
Immune response
Immunity, Innate - physiology
Immunological research
Inflammation
Inflammation - immunology
Inflammation - pathology
Ligands
Microglia - physiology
Neural circuitry
Neurodegenerative Diseases - immunology
Neurodegenerative Diseases - metabolism
Neurological research
Physiological aspects
Review
Signal Transduction
Toll-Like Receptors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful. Innate immune system consisting of pattern-recognition receptors, macrophages, and complement system plays a key role in CNS homeostasis following injury and infection. Here, we discuss how innate immune components can also contribute to neuroinflammation and neurodegeneration.
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/342931