Relationship between Salivary Alpha-2 Macroglobulin and HbA1c among Patients with Type-2 Diabetes Mellitus: A Cross-sectional Study

Context: Type-2 diabetes mellitus (DM2) requires an adequate glycemic control to avoid diabetic complications. The best parameter available is glycosylated hemoglobin (HbA1c), as it gives us an overview of an individuals' glycemic control of the previous 4 months. Salivary biomarkers used as a...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism 2019-03, Vol.23 (2), p.184-187
Main Authors: Rastogi, Vanshika, Kalra, Pramila, Vanitha Gowda, M
Format: Article
Language:English
Subjects:
Alpha 2 macroglobulin
Biological markers
Biomarkers
Cross-sectional studies
Development and progression
Diabetes
Diabetes mellitus
Diabetes therapy
Diabetic neuropathy
Fasting
Glucose
Glycemic index
Glycosylated hemoglobin
Hemoglobin
Hemoglobins
Medical research
Original
Population
salivary biomarker
Sample size
Type 2 diabetes
Variables
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Summary:Context: Type-2 diabetes mellitus (DM2) requires an adequate glycemic control to avoid diabetic complications. The best parameter available is glycosylated hemoglobin (HbA1c), as it gives us an overview of an individuals' glycemic control of the previous 4 months. Salivary biomarkers used as a diagnostic tool can indicate the control or degree of progression of diseases. Studies indicate that salivary alpha-2-macroglobulin (A2MG) levels are elevated in diabetes patients. Aims: To study the relationship of salivary A2MG with glycosylated Hba1c among patients with DM2. Settings and Design: A total of 87 patients of DM2, age 35-65 years were recruited. Materials and Methods: The routine oral cavity examination and dental check-up was done to rule out any dental disease. The patients with hepatic diseases and inflammatory diseases of oral cavity and body were excluded. The values of HbA1c were collected from the records of patients. Salivary A2MG levels were estimated by enzyme-linked immunosorbent assay. Levels of fasting and postprandial blood sugar, serum creatinine, and A2MG were compared with the HbA1c groups (
ISSN:2230-8210
2230-9500
DOI:10.4103/ijem.ijem_40_19