GRB2 is a BECN1 interacting protein that regulates autophagy

GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a mechanism involving the modulation of the class II...

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Published in:Cell death & disease 2024-01, Vol.15 (1), p.14-14, Article 14
Main Authors: Montero-Vergara, Jetsy, Plachetta, Kira, Kinch, Lisa, Bernhardt, Stephan, Kashyap, Kriti, Levine, Beth, Thukral, Lipi, Vetter, Martina, Thomssen, Christoph, Wiemann, Stefan, Peña-Llopis, Samuel, Jendrossek, Verena, Vega-Rubin-de-Celis, Silvia
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Language:English
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631/67/1347
631/80/39/2346
82/1
82/29
82/51
82/79
96/106
96/109
96/63
Adapter proteins
Adaptor Proteins, Signal Transducing
Animals
Antibodies
Autophagy
Autophagy - genetics
Beclin-1 - genetics
Biochemistry
Biomedical and Life Sciences
Breast cancer
Cancer research
Carcinogenesis
Cell Biology
Cell Culture
Cell death
Cell Transformation, Neoplastic
Chorioallantoic membrane
ErbB-2 protein
Genomics
Grb2 protein
Immunology
Kinases
Life Sciences
Medical research
Phosphorylation
Tumor cell lines
Tumorigenesis
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cited_by cdi_FETCH-LOGICAL-c485t-771dd262e6dfb494bf03e0212442c1d6db7d521509a126167ac288739b1016293
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container_title Cell death & disease
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creator Montero-Vergara, Jetsy
Plachetta, Kira
Kinch, Lisa
Bernhardt, Stephan
Kashyap, Kriti
Levine, Beth
Thukral, Lipi
Vetter, Martina
Thomssen, Christoph
Wiemann, Stefan
Peña-Llopis, Samuel
Jendrossek, Verena
Vega-Rubin-de-Celis, Silvia
description GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy through a mechanism involving the modulation of the class III PI3Kinase VPS34 activity. In ovo studies in a CAM (Chicken Chorioallantoic Membrane) model indicated that GRB2 knockdown, as well as overexpression of GRB2 loss-of-function mutants (Y52A and S86A-R88A) compromised tumor growth. These differences in tumor growth correlated with differential autophagy activity, indicating that autophagy effects might be related to the effects on tumorigenesis. Our data highlight a novel function of GRB2 as a BECN1 binding protein and a regulator of autophagy.
doi_str_mv 10.1038/s41419-023-06387-7
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subjects 631/67/1347
631/80/39/2346
82/1
82/29
82/51
82/79
96/106
96/109
96/63
Adapter proteins
Adaptor Proteins, Signal Transducing
Animals
Antibodies
Autophagy
Autophagy - genetics
Beclin-1 - genetics
Biochemistry
Biomedical and Life Sciences
Breast cancer
Cancer research
Carcinogenesis
Cell Biology
Cell Culture
Cell death
Cell Transformation, Neoplastic
Chorioallantoic membrane
ErbB-2 protein
Genomics
Grb2 protein
Immunology
Kinases
Life Sciences
Medical research
Phosphorylation
Tumor cell lines
Tumorigenesis
title GRB2 is a BECN1 interacting protein that regulates autophagy
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