Emerging Role of Eosinophils in Resolution of Arthritis

Eosinophils are a minor component of circulating granulocytes, which are classically viewed as end-stage effector cells in host defense against helminth infection and promoting allergic responses. However, a growing body of evidence has emerged showing that eosinophils are versatile leukocytes actin...

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Bibliographic Details
Published in:Frontiers in immunology 2021-10, Vol.12, p.764825-764825
Main Authors: Qin, Yi, Jin, Hui-Zhi, Li, Yu-Jing, Chen, Zhu
Format: Article
Language:English
Subjects:
alternatively activated macrophages
Arthritis, Rheumatoid - immunology
Cytokines - immunology
eosinophil
Eosinophils - immunology
Humans
Immunology
Inflammation - immunology
innate lymphoid cells
resolution
rheumatoid arthritis
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Summary:Eosinophils are a minor component of circulating granulocytes, which are classically viewed as end-stage effector cells in host defense against helminth infection and promoting allergic responses. However, a growing body of evidence has emerged showing that eosinophils are versatile leukocytes acting as an orchestrator in the resolution of inflammation. Rheumatoid arthritis (RA) is the most common chronic inflammatory disease characterized by persistent synovitis that hardly resolves spontaneously. Noteworthy, a specific population of eosinophils, that is, regulatory eosinophils (rEos), was identified in the synovium of RA patients, especially in disease remission. Mechanistically, the rEos in the synovium display a unique pro-resolving signature that is distinct from their counterpart in the lung. Herein, we summarize the latest understanding of eosinophils and their emerging role in promoting the resolution of arthritis. This knowledge is crucial to the design of new approaches to rebalancing immune homeostasis in RA, considering that current therapies are centered on inhibiting pro-inflammatory cytokines and mediators rather than fostering the resolution of inflammation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.764825