Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight

An 11–25% increase in total ventricular volume has been documented in astronauts following spaceflight on the ISS. Given the approximately 2-year time interval between pre- and post-flight MRI, it is unknown if ventricular enlargement simply reflects normal aging or is unique to spaceflight exposure...

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Bibliographic Details
Published in:Aging brain 2021-01, Vol.1, p.100017-100017, Article 100017
Main Authors: Roberts, Donna R., Inglesby, Dani C., Brown, Truman R., Collins, Heather R., Eckert, Mark A., Asemani, Davud
Format: Article
Language:English
Subjects:
Cerebral ventricles
Normal aging
Spaceflight
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Summary:An 11–25% increase in total ventricular volume has been documented in astronauts following spaceflight on the ISS. Given the approximately 2-year time interval between pre- and post-flight MRI, it is unknown if ventricular enlargement simply reflects normal aging or is unique to spaceflight exposure. Therefore, we compared percent ventricular volume change per year (PVVC/yr) documented on pre- to post-flight MRI in a group of NASA ISS astronauts (n = 18, 16.7% women, mean age (SD) 48.43 (4.35) years) with two groups who underwent longitudinal MRI: (1.) healthy age- and sex-matched adults (n = 18, 16.7% women, mean age (SD) 51.26 (3.88) years), and (2.) healthy older adults (n = 79, 16.5% women, mean age (SD) 73.26 (5.34) years). The astronauts, who underwent a mean (SD) 173.4 (51.3) days in spaceflight, showed a greater increase in PVVC/yr than the control (6.86 vs 2.23%, respectively, p 
ISSN:2589-9589
2589-9589
DOI:10.1016/j.nbas.2021.100017