Distinguished Functions of Microglia in the Two Stages of Oxygen-Induced Retinopathy: A Novel Target in the Treatment of Ischemic Retinopathy

Microglia is the resident immune cell in the retina, playing the role of immune surveillance in a traditional concept. With the heated focus on the mechanisms of microglia in pathological conditions, more and more functions of microglia have been discovered. Although the regulating role of microglia...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2022-10, Vol.12 (10), p.1676
Main Authors: Zhou, Ziyi, Jing, Yutong, Niu, Yali, Chang, Tianfang, Sun, Jiaxing, Guo, Changmei, Wang, Yusheng, Dou, Guorui
Format: Article
Language:English
Subjects:
Adaptation
Angiogenesis
Antibodies
Apoptosis
Diabetic retinopathy
Electrodes
Immune system
Immunoglobulins
Immunosurveillance
Ischemia
ischemic retinopathy
Laboratory animals
Microglia
Nervous system
Oxygen
Photoreceptors
PLX5622
Retina
Retinopathy
Software
Statistical analysis
vessel remodeling
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Summary:Microglia is the resident immune cell in the retina, playing the role of immune surveillance in a traditional concept. With the heated focus on the mechanisms of microglia in pathological conditions, more and more functions of microglia have been discovered. Although the regulating role of microglia has been explored in ischemic retinopathy, little is known about its mechanisms in the different stages of the pathological process. Here, we removed microglia in the oxygen-induced retinopathy model by PLX5622 and revealed that the removal of activated microglia reduced pathological angiogenesis in the early stage after ischemic insult and alleviated the over-apoptosis of photoreceptors in the vessel remodeling phase. Our results indicated that microglia might play distinguished functions in the angiogenic and remodeling stages, and that the inhibition of microglia might be a promising target in the future treatment of ischemic retinopathy.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12101676