Modulation of defensive reflex conditioning in snails by serotonin

Highlights Daily injection of serotonin before a training session accelerated defensive reflex conditioning in snails.Daily injection of 5-hydroxytryptophan before a training session in snails with a deficiency of serotonin induced by the "neurotoxic" analog of serotonin 5,7-dihydroxytrypt...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2015-10, Vol.9, p.279
Main Authors: Andrianov, Vyatcheslav V, Bogodvid, Tatiana K, Deryabina, Irina B, Golovchenko, Aleksandra N, Muranova, Lyudmila N, Tagirova, Roza R, Vinarskaya, Aliya K, Gainutdinov, Khalil L
Format: Article
Language:English
Subjects:
Acids
associative learning
Experiments
Gastropoda
identified neurons
Injection
Interneurons
Laboratory animals
Learning
membrane potential
Mollusks
Nervous system
Neurobiology
Neurons
Neuroscience
Neurosciences
Neurotoxicity
Neurotoxins
Serotonin
Snail
Threshold potential
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Summary:Highlights Daily injection of serotonin before a training session accelerated defensive reflex conditioning in snails.Daily injection of 5-hydroxytryptophan before a training session in snails with a deficiency of serotonin induced by the "neurotoxic" analog of serotonin 5,7-dihydroxytryptamine, restored the ability of snails to learn.After injection of the "neurotoxic" analogs of serotonin 5,6- and 5,7-dihydroxytryptamine as well as serotonin, depolarization of the membrane and decrease of the threshold potential of premotor interneurons was observed. We studied the role of serotonin in the mechanisms of learning in terrestrial snails. To produce a serotonin deficit, the "neurotoxic" analogs of serotonin, 5,6- or 5,7-dihydroxytryptamine (5,6/5,7-DHT) were used. Injection of 5,6/5,7-DHT was found to disrupt defensive reflex conditioning. Within 2 weeks of neurotoxin application, the ability to learn had recovered. Daily injection of serotonin before a training session accelerated defensive reflex conditioning and daily injections of 5-HTP in snails with a deficiency of serotonin induced by 5,7-DHT restored the snail's ability to learn. We discovered that injections of the neurotoxins 5,6/5,7-DHT as well as serotonin, caused a decrease in the resting and threshold potentials of the premotor interneurons LPa3 and RPa3.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2015.00279