Synthesis of porous silica hollow spheres using sacrificial template for drug delivery applications

In this work, we report on the synthesis of SiO2 hollow spheres using carbon nanospheres as the sacrificial template by hydrothermal method. The synthesized substrates are in a spherical morphology and uniform size distribution. The effects of hydrothermal process, concentration and the reaction tem...

Full description

Saved in:
Bibliographic Details
Published in:Current chemistry letters 2014-06, Vol.3 (3), p.141-146
Main Authors: Safdari, Rasoul, Afshar, Shahrara, Khosravi, Alireza
Format: Article
Language:English
Subjects:
Drug delivery
Sacrificial template
SiO2 hallow sphere
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, we report on the synthesis of SiO2 hollow spheres using carbon nanospheres as the sacrificial template by hydrothermal method. The synthesized substrates are in a spherical morphology and uniform size distribution. The effects of hydrothermal process, concentration and the reaction temperature were optimized during synthesis of carbon nanospheres. Infrared spectroscopy (IR), and scanning electronic microscopy (SEM) methods were used for identification of the synthesized products. The synthesized SiO2 nanospheres were used as drug carrier to investigate in vitro release behavior of monoterpenic phenol isomers, carvacrol and thymol, in simulated body fluid (SBF). Ultraviolet-visible spectroscopy (UV-vis) method was carried out to determine the amount of the drugs entrapped in the carrier. The results indicated that SiO2 nanospheres have high ability to adsorb the drugs and there is no need for adjusting the pH during the adsorption process. The drug release profile shows a three stages pattern and indicates a delayed release action.
ISSN:1927-7296
1927-730X
DOI:10.5267/j.ccl.2014.5.005