The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development

Primary cilia are microtube-based organelles that extend from the cell surface and function as biochemical and mechanical extracellular signal sensors. Primary cilia coordinate a series of signaling pathways during development. Cilia dysfunction leads to a pleiotropic group of developmental disorder...

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Bibliographic Details
Published in:Journal of developmental biology 2022-12, Vol.10 (4), p.51
Main Authors: Chen, Chuan, Hu, Jinghua, Ling, Kun
Format: Article
Language:English
Subjects:
Biosynthesis
Blood lipids
Cell surface
Cilia
Cytoskeleton
development
Disease
Homeostasis
Kinases
Localization
Mechanical properties
Membrane lipids
Membrane trafficking
Organelles
Phosphatase
Phosphatases
phosphoinositide kinases and phosphatases
Phosphoinositides
Phospholipids
Physiology
Plasma
primary cilia
Proteins
Review
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Summary:Primary cilia are microtube-based organelles that extend from the cell surface and function as biochemical and mechanical extracellular signal sensors. Primary cilia coordinate a series of signaling pathways during development. Cilia dysfunction leads to a pleiotropic group of developmental disorders, termed ciliopathy. Phosphoinositides (PIs), a group of signaling phospholipids, play a crucial role in development and tissue homeostasis by regulating membrane trafficking, cytoskeleton reorganization, and organelle identity. Accumulating evidence implicates the involvement of PI species in ciliary defects and ciliopathies. The abundance and localization of PIs in the cell are tightly regulated by the opposing actions of kinases and phosphatases, some of which are recently discovered in the context of primary cilia. Here, we review several cilium-associated PI kinases and phosphatases, including their localization along cilia, function in regulating the ciliary biology under normal conditions, as well as the connection of their disease-associated mutations with ciliopathies.
ISSN:2221-3759
2221-3759
DOI:10.3390/jdb10040051