Adhesion molecules: a way to understand lupus

Systemic lupus erythematosus is a connective disease in which all vitally important organs may be affected. The etiology of the disease is largely unknown and almost all immunological mechanisms have been proposed as the pathophysiological background of the disease. Among them, endothelial damage an...

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Bibliographic Details
Published in:Reumatologia 2022-01, Vol.60 (2), p.133-141
Main Authors: Nowak, Karolina, Gumkowska-Sroka, Olga, Kotyla, Przemysław
Format: Article
Language:English
Subjects:
Biomarkers
Cell adhesion & migration
Cell adhesion molecules
Clinical medicine
Clinical trials
Disease
endothelial biomarkers
Endothelial cells
endothelial dysfunction
Endothelium
Etiology
Heart
Immunocompetence
Immunology
Inflammation
Internal medicine
Kidneys
Lupus
Physiology
Review Paper
Rheumatology
Selectins
Skin
Systemic lupus erythematosus
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Summary:Systemic lupus erythematosus is a connective disease in which all vitally important organs may be affected. The etiology of the disease is largely unknown and almost all immunological mechanisms have been proposed as the pathophysiological background of the disease. Among them, endothelial damage and dysfunction seem to play a pivotal role. Endothelial damage can be accurately measured using adhesion molecules such asintercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), platelet endothelial cell adhesion molecule (PECAM) and selectins. In this review we discuss the role of well-known cellular adhesion molecules as pathogenic factors in disease development as well as disease activity biomarkers.
ISSN:0034-6233
2084-9834
DOI:10.5114/reum.2022.115664