Vasopressin modulates hypothalamo-pituitary activity by paracrine action during acute and chronic immobilization stress in rats

The aim of the study was to examine changes in corticotropin releasing hormone (CRH), vasopressin (VP), adrenocorticotropin (ACTH) as well as VP3 receptor protein concentration in the hypothalamus and the pituitary of rats exposed to acute (3 h) and chronically repeated (3 h daily for 7 days) immobi...

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Bibliographic Details
Published in:Archives of biological sciences 2011, Vol.63 (3), p.579-587
Main Authors: Lakic, Iva, Vujovic, P., Jasnic, N., Djurasevic, S., Cvijic, Gordana
Format: Article
Language:English
Subjects:
ADRENOCORTICOTROPIC HORMONE
CRH
ESTRES
GLAINDULA PITUITARIA
HIPOTAILAMO
HORMONA ADRENOCORTICOTROPICA
HORMONAS LIBERADORAS
HORMONE ADRANOCORTICOTROPE
http://www.fao.org/aos/agrovoc#c_11691
http://www.fao.org/aos/agrovoc#c_16028
http://www.fao.org/aos/agrovoc#c_26834
http://www.fao.org/aos/agrovoc#c_5939
http://www.fao.org/aos/agrovoc#c_6464
http://www.fao.org/aos/agrovoc#c_7452
http://www.fao.org/aos/agrovoc#c_8627
HYPOPHYSE
HYPOTHALAMUS
immobilization stress
pituitary
PITUITARY GLAND
RAT
RATA
RATS
RELEASING HORMONE
RELEASING HORMONES
STRESS
VASOPRESINA
VASOPRESSIN
VASOPRESSINE
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Summary:The aim of the study was to examine changes in corticotropin releasing hormone (CRH), vasopressin (VP), adrenocorticotropin (ACTH) as well as VP3 receptor protein concentration in the hypothalamus and the pituitary of rats exposed to acute (3 h) and chronically repeated (3 h daily for 7 days) immobilization stress. Our results show that, unlike the increase in ACTH, there were no changes in serum VP despite the significant changes in this hormone and its receptor concentrations in the hypothalamus and pituitary (HP). This suggests that VP regulates HP activity by predominantly acting in a paracrine manner under the examined stress condition.
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS1103579L