Effect of low-intensity pulsed ultrasound on injured temporomandibular joints with or without articular disc removal in a rabbit model

Dynamic stimulation can induce bone and cartilage growth. The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) on injured temporomandibular joints (TMJs) in a rabbit model. Twenty-four female Japanese white rabbits (age: 12–16 weeks, weight: 2.0–2.5 kg) were...

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Bibliographic Details
Published in:Journal of dental sciences 2021-01, Vol.16 (1), p.287-295
Main Authors: Saito, Yuki, Tsutsui, Takamitsu, Takayama, Akihiro, Moroi, Akinori, Yoshizawa, Kunio, Ueki, Koichiro
Format: Article
Language:English
Subjects:
Cartilage
Discectomy
Low-intensity pulsed ultrasound (LIPUS)
Mandibular length
Original
Temporomandibular joint
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Summary:Dynamic stimulation can induce bone and cartilage growth. The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) on injured temporomandibular joints (TMJs) in a rabbit model. Twenty-four female Japanese white rabbits (age: 12–16 weeks, weight: 2.0–2.5 kg) were equally divided into 4 groups. In two groups, discectomy was performed with (the LD group) and without (the D group) subsequent LIPUS treatment. In the other groups, a sham operation was performed with (the LC group) and without (the C group) subsequent LIPUS treatment. Two animals in each group were sacrificed at each time point (2, 4, and 8 weeks postoperatively). Mandibular measurements were made using three-dimensional computed tomography. We performed histological and immunohistochemical examination of the articular disc, and the cartilage layer and bone at the 30- and 60-degree sites in each condyle. There were no statistically significant differences among the groups in terms of thickness of the disc or the fibrous articular zone, or the number of BMP-2 positive cells. In terms of mandibular length, there were differences among the groups after 4 (P = 0.0498) and 8 weeks (P = 0.0260). Specifically, there was a difference between the LC group and the C group after 4 weeks (P = 0.014) and 8 weeks (P = 0.029). This study suggests that LIPUS has little effect on cartilage after TMJ injury. It may promote bone growth in a normal TMJ, although discectomy seems to reduce this effect.
ISSN:1991-7902
2213-8862
DOI:10.1016/j.jds.2020.04.002