Development of Insulin Resistance in Patients with Epilepsy During Valproate and Carbamazepine Monotherapy

Objectives:This study investigated the development of insulin resistance (IR) secondary to the use of valproic acid (VPA) and carbamazepine (CBZ), which are highly effective and frequently used antiepileptic drugs.Methods:This cross-sectional prospective cohort study included 111 participants aged 1...

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Bibliographic Details
Published in:Archives of Epilepsy 2016-12, Vol.22 (3), p.102-107
Main Authors: Selda KESKİN GÜLER, Nalan GÜNEŞ, Burcu Gökçe ÇOKAL, Tahir YOLDAŞ, Elif Banu SÖKER
Format: Article
Language:English
Subjects:
c-peptide
carbamazepine
insulin resistance
valproic acid
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Summary:Objectives:This study investigated the development of insulin resistance (IR) secondary to the use of valproic acid (VPA) and carbamazepine (CBZ), which are highly effective and frequently used antiepileptic drugs.Methods:This cross-sectional prospective cohort study included 111 participants aged 15 to 64 years. Patients diagnosed with epilepsy were divided into 2 groups: those using VPA (n=45) and those using CBZ (n=35). Those groups were compared to healthy control group (n=31). Preprandial blood glucose, insulin, C-peptide levels were examined, and IR was calculated. Anthropometric measurements were taken.Results:A significant relationship was identified between VPA or CBZ use and development of IR (p
ISSN:2792-0550
DOI:10.5505/epilepsi.2016.88700