Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients

The prognostic value of multiple glycemic parameters in poisoned patients was never assessed. We aim to explore the effects of glucose variability on short-term outcomes in nondiabetic and diabetic patients acutely poisoned with undifferentiated xenobiotics. We performed a prospective observational...

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Bibliographic Details
Published in:Diagnostics (Basel) 2021-02, Vol.11 (2), p.361
Main Authors: Lionte, Catalina, Bologa, Cristina, Agafiti, Inga, Sorodoc, Victorita, Petris, Ovidiu Rusalim, Jaba, Elisabeta, Sorodoc, Laurentiu
Format: Article
Language:English
Subjects:
Alcohol
Diabetes
Glucose
glucose variability
glycemia
Hospitalization
Hospitals
Hyperglycemia
Hypoglycemia
Laboratories
mean glucose level
Mortality
outcomes
Patients
Pesticides
Poisoning
Prescription drugs
Toxins
xenobiotics
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Summary:The prognostic value of multiple glycemic parameters in poisoned patients was never assessed. We aim to explore the effects of glucose variability on short-term outcomes in nondiabetic and diabetic patients acutely poisoned with undifferentiated xenobiotics. We performed a prospective observational study in a tertiary center for toxicology in northeastern Romania. Over the course of 3 years, we included 1076 adults, older than 18 years, admitted for acute poisoning with a xenobiotic. The mortality rate was 4.1%. The admission blood glucose level (BGL) predicted mortality (OR 1.015, 95% CI 1.011-1.019, < 0.001) and complications (OR 1.005, 95% CI 1.001-1.009, 0.02). The mean glucose level (MGL) after admission (OR 1.007, 95% CI 1.000-1.013, 0.034) and coefficient of glucose variability (CV) were predictive for complications (OR 40.58, 95% CI 1.35-1220.52, 0.033), using the same multivariable model. The receiver operating characteristic curve (ROC) analysis revealed that BGL had good predictive value for in-hospital mortality (area under the curve (AUC) = 0.744, 95% CI = 0.648-0.841, < 0.001), and complications (AUC = 0.618, 95% CI = 0.584-0.653, < 0.001). In patients acutely poisoned with xenobiotics, the BGL, MGL and CV can be useful as mortality and short-outcome predictors.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics11020361