Molecular Imaging of Tau Protein: New Insights and Future Directions

Tau is a microtubule-associated protein (MAPT) that is highly expressed in neurons and implicated in several cellular processes. Tau misfolding and self-aggregation give rise to proteinaceous deposits known as neuro-fibrillary tangles. Tau tangles play a key role in the genesis of a group of disease...

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Bibliographic Details
Published in:Frontiers in molecular neuroscience 2020-12, Vol.13, p.586169-586169
Main Authors: Pizzarelli, Rocco, Pediconi, Natalia, Di Angelantonio, Silvia
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Biomarkers
BODIPY
Brain research
Fluorescent indicators
Microscopy
near-infrared fluorescent probes
Neurodegeneration
Neurodegenerative diseases
Neuroscience
Patients
Physiology
Proteins
Structure-function relationships
super-resolution imaging
tau
Tau protein
Visualization
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Summary:Tau is a microtubule-associated protein (MAPT) that is highly expressed in neurons and implicated in several cellular processes. Tau misfolding and self-aggregation give rise to proteinaceous deposits known as neuro-fibrillary tangles. Tau tangles play a key role in the genesis of a group of diseases commonly referred to as tauopathies; notably, these aggregates start to form decades before any clinical symptoms manifest. Advanced imaging methodologies have clarified important structural and functional aspects of tau and could have a role as diagnostic tools in clinical research. In the present review, recent progresses in tau imaging will be discussed. We will focus mainly on super-resolution imaging methods and the development of near-infrared fluorescent probes.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2020.586169