Antioxidant activity of extracts of Momordica foetida Schumach. et Thonn

Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is a perennial climbing herb with tendrils, found in swampy areas in Central Uganda. Antidiabetic and antilipogenic activities were reported for some Momordica species, however the mechanism of action is still unknown. Oxidative stress may repres...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2013-03, Vol.18 (3), p.3241-3249
Main Authors: Acquaviva, Rosaria, Di Giacomo, Claudia, Vanella, Luca, Santangelo, Rosa, Sorrenti, Valeria, Barbagallo, Ignazio, Genovese, Carlo, Mastrojeni, Silvana, Ragusa, Salvatore, Iauk, Liliana
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - drug effects
Adipocytes - metabolism
adipogenic differentiation
Antidiabetics
antioxidant activity
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Flavonoids
Flavonoids - chemistry
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Free radicals
Humans
Hypotheses
Leaves
Lipid peroxidation
Lipids
Metabolic syndrome
Momordica - chemistry
Momordica foetida Schumach. et Thonn
Obesity
Oxidative stress
Plant Extracts - chemistry
Plant Leaves - chemistry
Plasma
Polyphenols
Polyphenols - chemistry
Stem cells
Superoxides - antagonists & inhibitors
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Summary:Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is a perennial climbing herb with tendrils, found in swampy areas in Central Uganda. Antidiabetic and antilipogenic activities were reported for some Momordica species, however the mechanism of action is still unknown. Oxidative stress may represent an important pathogenic mechanism in obesity-associated metabolic syndrome. The present study evaluated free radical scavenging capacity of different concentrations of aqueous, methanolic and dichloromethane leaf extracts of Momordica foetida Schumach. et Thonn. and the ability of these extracts to inhibit in vitro plasma lipid peroxidation; in addition, healthy human adipose mesenchymal stem cell cultures were used in order to test the hypothesis that these extracts may affect adipocyte differentiation. Results obtained in this study suggested that aqueous extract might be useful in preventing metabolic syndrome.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18033241