Antibiotic Susceptibility Patterns for Carbapenem-Resistant Enterobacteriaceae

Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibio...

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Bibliographic Details
Published in:International journal of microbiology 2023-02, Vol.2023, p.8920977-5
Main Authors: Armin, Shahnaz, Fallah, Fatemeh, Karimi, Abdollah, Karbasiyan, Fereshteh, Alebouyeh, Masoud, Rafiei Tabatabaei, Sedigheh, Rajabnejad, Maryam, Mansour Ghanaie, Roxana, Fahimzad, Seyed Alireza, Abdollahi, Nafiseh, Khodaei, Hannan, Azimi, Leila
Format: Article
Language:English
Subjects:
Amides
Antibiotic resistance
Antibiotics
Antimicrobial agents
Aztreonam
Bacteria
Bacterial pneumonia
Beta lactamases
Colistin
CRE bacteria
Drug resistance
Drug therapy
E coli
Enterobacter
Enterobacteriaceae
Enzymes
Escherichia coli
FDA approval
Fosfomycin
Gram-negative bacteria
Health aspects
Health risks
Hospitals
Imipenem
Klebsiella
Klebsiella pneumoniae
Laboratories
Levofloxacin
Meropenem
Metronidazole
Microbiology
Nosocomial infections
Pneumonia
Public health
Rifampin
Sensitivity
Tigecycline
β-Lactam antibiotics
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Summary:Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibiotic susceptibility pattern of carbapenem-resistant Enterobacteriaceae (CRE) to new and old antibiotics. In this study, Klebsiella pneumoniae, E. coli, and Enterobacter spp. were collected from 10 hospitals in Iran for one year. CRE is recognized by resistance to meropenem and/or imipenem disk after identification of the collected bacteria. Antibiotic susceptibility of CRE against fosfomycin, rifampin, metronidazole, tigecycline, and aztreonam was detected by disk diffusion method and colistin by MIC. In this study, 1222 E. coli, 696 K. pneumoniae, and 621 Enterobacter spp. were collected from 10 hospitals in Iran in one year. Fifty-four E. coli (4.4%), 84 K. pneumoniae (12%), and 51 Enterobacter spp. (8.2%) were CRE. All CRE strains were resistant to metronidazole and rifampicin. Tigecycline has the highest sensitivity on CRE and levofloxacin for Enterobacter spp. Tigecycline showed an acceptable effectiveness rate of sensitivity on the CRE strain. Therefore, we suggest that clinicians consider this valuable antibiotic to treat CRE.
ISSN:1687-918X
1687-9198
DOI:10.1155/2023/8920977