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Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study
a herb used as food and also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage. In addition to other characterized properties, it possesses antifertility and anti-implantation activities. This study investigates the testicular toxicity of the testes of offsprings...
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| Published in: | International journal of reproductive biomedicine (Yazd, Iran) Iran), 2023-03, Vol.21 (3), p.237-244 |
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| Language: | English |
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| container_title | International journal of reproductive biomedicine (Yazd, Iran) |
| container_volume | 21 |
| creator | Eguono Uwejigho, Raphael Afoke Iteire, Kingsley Udawmojo Enemali, Felix |
| description | a herb used as food and also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage. In addition to other characterized properties, it possesses antifertility and anti-implantation activities.
This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of
.
25 pregnant Wistar rats (Dams) weighing 180-240 gr were randomly earmarked into 5 groups (n = 5/each). Group A served as control; groups B, C, D, and E received 200, 400, 800, and 1000 mg/kg body weight of
extract
respectively, beginning from 12
to 19
day of gestation. The pups (delivered of Dams) were weighed, observed, and sacrificed 6 wk post-parturition. The testes of the male pups were obtained for histological procedures the testis histology was examined.
No gross malformation was observed in the treatment groups, the number of pups/litter was significantly reduced in group E (p= 0.01), pups weight analysis showed a significant reduction in groups C and E (p= 0.04, and 0.02 respectively), and the mean pup testes weight was significantly reduced in groups B, C, D, and E (p= 0.03, 0.03, 0.01, and
0.001 respectively) when compared with control. Histologically, the treated pup testes tissues showed varying degrees of disruption and distortion of the cellular arrangements of the germinal epithelium in a dose dependent manner compared to the control.
The study revealed a testicular toxicity and possibly antifertility role of
in dams' pups. |
| doi_str_mv | 10.18502/ijrm.v21i3.13199 |
| format | article |
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This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of
.
25 pregnant Wistar rats (Dams) weighing 180-240 gr were randomly earmarked into 5 groups (n = 5/each). Group A served as control; groups B, C, D, and E received 200, 400, 800, and 1000 mg/kg body weight of
extract
respectively, beginning from 12
to 19
day of gestation. The pups (delivered of Dams) were weighed, observed, and sacrificed 6 wk post-parturition. The testes of the male pups were obtained for histological procedures the testis histology was examined.
No gross malformation was observed in the treatment groups, the number of pups/litter was significantly reduced in group E (p= 0.01), pups weight analysis showed a significant reduction in groups C and E (p= 0.04, and 0.02 respectively), and the mean pup testes weight was significantly reduced in groups B, C, D, and E (p= 0.03, 0.03, 0.01, and
0.001 respectively) when compared with control. Histologically, the treated pup testes tissues showed varying degrees of disruption and distortion of the cellular arrangements of the germinal epithelium in a dose dependent manner compared to the control.
The study revealed a testicular toxicity and possibly antifertility role of
in dams' pups.</description><identifier>ISSN: 2476-4108</identifier><identifier>EISSN: 2476-3772</identifier><identifier>DOI: 10.18502/ijrm.v21i3.13199</identifier><identifier>PMID: 37122890</identifier><language>eng</language><publisher>Iran: Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility</publisher><subject>amaranthaceae, fertility, male fertility, male reproductive system, local herbs ; Drug dosages ; Ethanol ; Fertility ; Herbal medicine ; Histology ; Miscarriage ; Motility ; Original ; Pregnancy ; Rodents ; Sperm ; Testes</subject><ispartof>International journal of reproductive biomedicine (Yazd, Iran), 2023-03, Vol.21 (3), p.237-244</ispartof><rights>Copyright © 2023 Uwejigho et al.</rights><rights>2023. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023 Uwejigho et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-4328-6769</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2831405284/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2831405284?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37122890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eguono Uwejigho, Raphael</creatorcontrib><creatorcontrib>Afoke Iteire, Kingsley</creatorcontrib><creatorcontrib>Udawmojo Enemali, Felix</creatorcontrib><title>Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study</title><title>International journal of reproductive biomedicine (Yazd, Iran)</title><addtitle>Int J Reprod Biomed</addtitle><description>a herb used as food and also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage. In addition to other characterized properties, it possesses antifertility and anti-implantation activities.
This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of
.
25 pregnant Wistar rats (Dams) weighing 180-240 gr were randomly earmarked into 5 groups (n = 5/each). Group A served as control; groups B, C, D, and E received 200, 400, 800, and 1000 mg/kg body weight of
extract
respectively, beginning from 12
to 19
day of gestation. The pups (delivered of Dams) were weighed, observed, and sacrificed 6 wk post-parturition. The testes of the male pups were obtained for histological procedures the testis histology was examined.
No gross malformation was observed in the treatment groups, the number of pups/litter was significantly reduced in group E (p= 0.01), pups weight analysis showed a significant reduction in groups C and E (p= 0.04, and 0.02 respectively), and the mean pup testes weight was significantly reduced in groups B, C, D, and E (p= 0.03, 0.03, 0.01, and
0.001 respectively) when compared with control. Histologically, the treated pup testes tissues showed varying degrees of disruption and distortion of the cellular arrangements of the germinal epithelium in a dose dependent manner compared to the control.
The study revealed a testicular toxicity and possibly antifertility role of
in dams' pups.</description><subject>amaranthaceae, fertility, male fertility, male reproductive system, local herbs</subject><subject>Drug dosages</subject><subject>Ethanol</subject><subject>Fertility</subject><subject>Herbal medicine</subject><subject>Histology</subject><subject>Miscarriage</subject><subject>Motility</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Rodents</subject><subject>Sperm</subject><subject>Testes</subject><issn>2476-4108</issn><issn>2476-3772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk9vEzEQxVcIRKvSD8AFWeLCZYPH9tpeLigqLVSqxAXOlu2dDY72T7C9Efn2mCRUlJMtz2-eZp5fVb0GugLdUPY-bOO42jMIfAUc2vZZdcmEkjVXij0_3wVQfVFdp7SllIJsABh_WV1wBYzpll5Wdj3lUPcYcxhCPhDse_SZzD1ZY9xbMtjJZkt8XDok-CtHW6phIqMdkHyyYypon3YxTJsPZD0VZIcxjDhlO5CUl-7wqnrR2yHh9fm8qr7f3X67-VI_fP18f7N-qL0QMtcOvPbcUa04slZw5EIJcI47KaVijKq-sULzhlIpbW-VUlI7prXT6EXhrqr7k243260pE402Hsxsgzk-zHFjbNnSD2iUxGJEh84JJxTzrVQouWNCYNOBx6L18aS1W9yInS_rRDs8EX1amcIPs5n3BihwrjgrCu_OCnH-uWDKZgzJ41D8xHlJhmmqGbC2bQv69j90Oy9xKl4VioOgDdOiUHCifJxTitg_TgPUHANh_gTCHANhjoEoPW_-XeOx4-_389_EU7I-</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Eguono Uwejigho, Raphael</creator><creator>Afoke Iteire, Kingsley</creator><creator>Udawmojo Enemali, Felix</creator><general>Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility</general><general>Knowledge E</general><general>Shahid Sadoughi University of Medical Sciences</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4328-6769</orcidid></search><sort><creationdate>20230301</creationdate><title>Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study</title><author>Eguono Uwejigho, Raphael ; Afoke Iteire, Kingsley ; Udawmojo Enemali, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-b1c8c3b0873e2943e34741bb3b66672207f5a48350066afa77768b288b8ec4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>amaranthaceae, fertility, male fertility, male reproductive system, local herbs</topic><topic>Drug dosages</topic><topic>Ethanol</topic><topic>Fertility</topic><topic>Herbal medicine</topic><topic>Histology</topic><topic>Miscarriage</topic><topic>Motility</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Rodents</topic><topic>Sperm</topic><topic>Testes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eguono Uwejigho, Raphael</creatorcontrib><creatorcontrib>Afoke Iteire, Kingsley</creatorcontrib><creatorcontrib>Udawmojo Enemali, Felix</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of reproductive biomedicine (Yazd, Iran)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eguono Uwejigho, Raphael</au><au>Afoke Iteire, Kingsley</au><au>Udawmojo Enemali, Felix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study</atitle><jtitle>International journal of reproductive biomedicine (Yazd, Iran)</jtitle><addtitle>Int J Reprod Biomed</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>21</volume><issue>3</issue><spage>237</spage><epage>244</epage><pages>237-244</pages><issn>2476-4108</issn><eissn>2476-3772</eissn><abstract>a herb used as food and also consumed as a tonic by pregnant women to relieve stomach pains and prevent miscarriage. In addition to other characterized properties, it possesses antifertility and anti-implantation activities.
This study investigates the testicular toxicity of the testes of offsprings of Dams treated with crude aqueous extract of
.
25 pregnant Wistar rats (Dams) weighing 180-240 gr were randomly earmarked into 5 groups (n = 5/each). Group A served as control; groups B, C, D, and E received 200, 400, 800, and 1000 mg/kg body weight of
extract
respectively, beginning from 12
to 19
day of gestation. The pups (delivered of Dams) were weighed, observed, and sacrificed 6 wk post-parturition. The testes of the male pups were obtained for histological procedures the testis histology was examined.
No gross malformation was observed in the treatment groups, the number of pups/litter was significantly reduced in group E (p= 0.01), pups weight analysis showed a significant reduction in groups C and E (p= 0.04, and 0.02 respectively), and the mean pup testes weight was significantly reduced in groups B, C, D, and E (p= 0.03, 0.03, 0.01, and
0.001 respectively) when compared with control. Histologically, the treated pup testes tissues showed varying degrees of disruption and distortion of the cellular arrangements of the germinal epithelium in a dose dependent manner compared to the control.
The study revealed a testicular toxicity and possibly antifertility role of
in dams' pups.</abstract><cop>Iran</cop><pub>Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility</pub><pmid>37122890</pmid><doi>10.18502/ijrm.v21i3.13199</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4328-6769</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of reproductive biomedicine (Yazd, Iran), 2023-03, Vol.21 (3), p.237-244 |
| issn | 2476-4108 2476-3772 |
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| subjects | amaranthaceae, fertility, male fertility, male reproductive system, local herbs Drug dosages Ethanol Fertility Herbal medicine Histology Miscarriage Motility Original Pregnancy Rodents Sperm Testes |
| title | Anti-fertility effect of Aerva lanata crude extract in male Dams offspring: An experimental study |
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