Risk Factors for Mortality in Sepsis Patients without Lactate Levels Increasing Early

Objectives. Our purpose was to investigate the influencing factors for mortality in sepsis patients without lactate levels increasing in the early stage. Methods. We conducted a retrospective observational study involving 830 adult sepsis patients admitted to ICU. We calculated time-weighted lactate...

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Bibliographic Details
Published in:Emergency medicine international 2023-02, Vol.2023, p.6620157-10
Main Authors: He, Miao, Huang, Jialin, Li, Xingxing, Liang, Shunda, Wang, Qing, Zhang, Hong
Format: Article
Language:English
Subjects:
Blood
Chronic kidney failure
Infection
Medical examination
Medical research
Medicine, Experimental
Mortality
Patient outcomes
Prognosis
Risk factors
Septic shock
Taiwan
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Summary:Objectives. Our purpose was to investigate the influencing factors for mortality in sepsis patients without lactate levels increasing in the early stage. Methods. We conducted a retrospective observational study involving 830 adult sepsis patients admitted to ICU. We calculated time-weighted lactate (LacTW), a dynamic value that incorporates both the magnitude of change and the time interval of such change, to represent lactate levels in the first 24 hours. ROC curve was used to find the cutoff of LacTW for predicting mortality, and the influencing factors for lactate levels and mortality in the low lactate group were further studied. The primary outcome was hospital mortality. Results. Among 830 patients, LacTW > 1.975 mmo/L was found to be the cutoff threshold for predicting mortality (AUC = 0.646, P 
ISSN:2090-2840
2090-2859
DOI:10.1155/2023/6620157