Interactions of host miRNAs in the flavivirus 3´UTR genome: From bioinformatics predictions to practical approaches

The genus Flavivirus of the family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect huma...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-10, Vol.12, p.976843-976843
Main Authors: Avila-Bonilla, Rodolfo Gamaliel, Salas-Benito, Juan Santiago
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Animals
antivirals
arthropod-borne viruses
Cellular and Infection Microbiology
Computational Biology
Encephalitis, Japanese - genetics
Flavivirus - genetics
Humans
MicroRNAs
MicroRNAs - genetics
non-translated regions
vaccines
Zika Virus - genetics
Zika Virus Infection
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Summary:The genus Flavivirus of the family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect humans, causing fever, encephalitis, or haemorrhagic fever. The treatment resources for these diseases and the number of vaccines available are limited. It has been discovered that eukaryotic cells synthesize small RNA molecules that can bind specifically to sequences present in messenger RNAs to inhibit the translation process, thus regulating gene expression. These small RNAs have been named microRNAs, and they have an important impact on viral infections. In this review, we compiled the available information on miRNAs that can interact with the 3' untranslated region (3'UTR) of the flavivirus genome, a conserved region that is important for viral replication and translation.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.976843