Adjunctive use of Ketorolac for Postoperative Pain Management in Elective Cardiac Surgery Patients: A Randomized Control Trial

Objective: To compare between the efficacy of Ketorolac and Paracetamol in the management of post-operative pain following elective cardiac surgery. Study Design: Randomized (single-blind) Control Trial (RCT NCT05361824.) Place and Duration of Study: This study was conducted in the Surgical Intensiv...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2022-10, Vol.72 (SUPPL-3), p.S585-90
Main Authors: Muzaffar, Maaida, Khuwaja, Amin M., Ahmed, Aftab, Iqtdar, Rabia, Chohan, Haris Tariq, Siddiqi, Rashad
Format: Article
Language:English
Subjects:
Acetaminophen
Analgesia
Assaults
Bones
Cardiac patients
Care and treatment
Coronary artery bypass
Coronary artery bypass grafting
Coronary artery disease
Coronary heart disease
Fractures
Hospital patients
Intervention
Ketorolac
Males
Nalbuphine
Nonsteroidal anti-inflammatory drugs
Pain
Pain management
Pain, Postoperative
Paracetamol
Patients
Postoperative pain
Postoperative period
Sports injuries
Surgical site infections
Traffic
Trauma
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Summary:Objective: To compare between the efficacy of Ketorolac and Paracetamol in the management of post-operative pain following elective cardiac surgery. Study Design: Randomized (single-blind) Control Trial (RCT NCT05361824.) Place and Duration of Study: This study was conducted in the Surgical Intensive Care Unit (SICU) at the National Institute of Cardiovascular Diseases Hospital, Karachi Pakistan, From 1st Jan to 30th Jun 2021. Methodology: Randomization of 60 patients undergoing elective cardiac surgery into either Paracetamol (30 control patients) or Ketorolac (30 treatment patients) was done.In addition, to a low dose, short duration background infusion of Nalbuphine, the control group was administered. Injection Paracetamol 1gm every six-hours. Whereas the treatment group was administered injection Ketorolac 30mg every eight-hours. Assessment of pain was done at 6, 12, 18 and 24 hours post-extubation, using a Visual analog scale (VAS). For the purpose of this study, a score of 4 or less was taken as a cut-off for adequate pain control. Results: VAS score was significantly lower in Ketorolac group as compared to the Paracetamol group at all four-time points with an average rating of 3.2±1.9 vs. 5.3±1.7; p
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v72iSUPPL-3.9559