Association Between MIND Diet Adherence and Mortality: Insights from Diabetic and Non-Diabetic Cohorts

• Published in: Nutrition & diabetes 2023-10, Vol.13 (1), p.18-18, Article 18
• Main Authors: Song, Yanjun, Chang, Zhen’ge, Song, Chenxi, Cui, Kongyong, Shi, Boqun, Zhang, Rui, Dong, Qiuting, Dou, Kefei
• Format: Article
• Language: English
• Subjects: 692/699/2743/137/773; 692/700/2814; Clinical Nutrition; Cohort Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Diet; Epidemiology; Humans; Hypertension; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Nutrition Surveys
• ISSN: 2044-4052; 2044-4052
• DOI: 10.1038/s41387-023-00247-1

Background/Objectives To date, evidence regarding the protective roles of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet in patients with type 2 diabetes mellitus (T2DM) is scarce. This study aims to estimate the impact of adhering to the MIND diet on the mortality in patients with and without T2DM. Subjects/Methods In this cohort study, 6887 participants (1021 patients with T2DM) from the NHANES dataset were analyzed. The exposure is the MIND diet adherence. The primary outcomes are all-cause and cardiovascular (CV) deaths. Results We documented 1087 all-cause deaths consisting of 377 CV deaths during the follow-up (median time of 10 years). Among participants with T2DM, those with a high MIND score (> 8.0, range of MIND score: 4.5–13) had a significantly lower risk of all-cause death (hazard ratio [HR] 0.75, 95% confidence interval [CI]: 0.59, 0.96, P  = 0.021) and CV death (HR 0.50, 95% CI: 0.29, 0.87, P  = 0.014) compared to those with a low MIND score (≤ 8.0). In participants without T2DM, a high MIND score was associated with a significant decrease in the risk of all-cause death (HR = 0.83, 95% CI: 0.70, 0.99, P