Innovative biodegradable dibutyrylchitin dressing for the treatment of ulcers occurring during chronic venous insufficiency in patients with type 2 diabetes

• Published in: International journal of occupational medicine and environmental health 2021-01, Vol.34 (4), p.565-573
• Main Authors: Bieniek, Ewa, Skołucka-Szary, Karolina, Brzeziński, Jan, Piaskowski, Sylwester, Lewiński, Andrzej
• Format: Article
• Language: English
• Subjects: Antithrombin; Biodegradability; biodegradable dressing; Biodegradation; Biomedical materials; Blood vessels; Care and treatment; Case studies; Cell adhesion; Chitin; chronic venous insufficiency; Clinical trials; Collagen; Complications and side effects; Compression therapy; Cytokines; Degradation; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetic ulcers; dibutyrylchitin; Disease; Drying; Enzymes; Fibrin; Gas exchange; Glycosylation; Granulation; Growth factors; Hyperglycemia; Immune system; Leg ulcers; Older people; Patients; Plasma membranes; professional capacity; Risk analysis; Risk factors; Scaffolding; Stiffness; Surgical dressings; Type 2 diabetes; Ulcers; Venous insufficiency; venous ulcers; Wound healing; Wounds
• ISSN: 1232-1087; 1896-494X
• DOI: 10.13075/ijomeh.1896.01670

The aim of this study was to assess the course of the healing process following the use of dibutyrylchitin (DBC) dressing, a fully degradable material used in the treatment of ulcers which occur during chronic venous insufficiency common in patients suffering from type 2 diabetes. These diseases have a significant impact on the patients' standard of living, including the potential employment, and on the declining attendance at the current workplace. The implementation of this innovative therapeutic solution may positively affect the above-mentioned difficulties. An analysis of the healing process, following the application of the DBC dressing, was performed. Once the dressing was positioned on the wound, the analysis indicated that it underwent a process of degradation facilitated by the enzymes occurring naturally in the wound. When fully degraded, a further layer was applied. This process was repeated until the wound was fully healed. The study group consisted of 4 patients previously diagnosed with type 2 diabetes. During the observation period, the ulcers in all 4 cases had healed. The examined wound dressings adhered well to the wound surface and degraded within it. No side effects or adverse effects of the applied innovative therapy were observed. An addition of the biodegradable DBC dressing to the standard therapy procedure of ulcers occurring during chronic venous insufficiency among patients with type 2 diabetes indicate safe and effective treatment, which may have a direct reflection in the patient's professional capacity enhancement. It resulted in the complete healing of all ulcers in each of the observed cases.